The anticoagulant activity of fucoidan from the brown alga Saccharina japonica in vivo

In experiments on rats anticoagulant, antiplatelet activity of fucoidan extracted from brown algae Saccharina japonica was evaluated. Fucoidan was administered intravenously in doses of 0,31, 1,25 and 2,5 mg/kg, 15-20 minutes before blood sampling. In the blood plasma was determined activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and the amount of fibrinogen and platelet aggregation and its amount. Fucoidan has provided dose-dependent anticoagulant effect. The most sensitive tests were TV and APTT. In fucoidan concentration 1.25 mg/kg thrombin time test was increased in 1.74 times, while the APTT test – in 3.24 times as compared with control (p