Arachidonil-lipids of blood mononuclear cells as a biomarker for early detection of different tumors

The regularities of quick (5 sec) incorporation of exogenous [14C]arachidonic acid (AA) into the various fractions of phospholipids (PL) and neutral lipids (NL) and it’s long-term (60 min) interfractional conversions in crude mononuclear cells (MNC) isolated from the peripheral blood of patients with breast (BC) and ovarian (OC) cancers in comparison with the healthy people was examined in the article. The data obtained provide evidence for reliable and identical disturbances in the MNC membrane lipids quick as well as long-term AA-modification mechanisms in BC and OC. We concluded that in the peripheral blood MNC some of the mechanisms responsible for fatty acid-content modification of lipids by AA are involved in the pathogenesis of BC and OC.