Associations of the TNFSF11 gene polymorphisms with knee osteoarthritis in postmenopausal women

Objective: to determine the role of the TNFSF11 gene polymorphisms rs9594738 and rs9594759 inthe development of knee osteoarthritis in postmenopausal women. Material and methods. The case-control studyincluded 483 postmenopausal women. Of these 157 were diagnosed with primary knee osteoarthritis. The remaining 326 women without signs of joint disease were included in the control group. Molecular genetic studies includeddetermination of TNFSF11 rs9594738 and TNFSF11 rs9594759 gene polymorphisms using the real-time polymerasechain reaction.