Association between genetic determinants of clopidogel metabolism and clinical cardiovascular risk indicators in Buryat patients

Background. In some patients, the metabolism of clopidoarel is altered because of the presence of polymorphic variants rs4244285 (* 2), rs4986893 (* 3) and rs12248560 (* 17) in the CYP2C19 aene. There is also evidence of decreased efficacy of clopidoarel in individuals with the T/T aenotype in the variant rs2305948 of the VEGFR-2 aene. Nevertheless, this medication is used widely in Russia due to the availability of aeneric anticoaaulants. Aim. To assess the prevalence of the followina polymorphic variants of CYP2C19 rs4244285 (* 2), rs4986893 (* 3) and rs12248560 (* 17); assess the prevalence of the rs2305948 variant of VEGFR-2, and determine cardiovascular risk factors in patients of Buryat nationality. Methods. The study included 113 patients of Buryat nationality who underwent coronary stent placement due to acute coronary syndrome. Patients were stratified by the presence of the followina alleles: CYP2C19 * 2, *3, *17 and VEGFR-2 rs2305948. The followina laboratory parameters were measured for all patients: blood alucose, lipid spectrum, creatinine, and alomerular filtration rate. The severity of coronary atherosclerosis was evaluated. Results. The frequencies of the alleles and halotypes (CYP2C19 * 2, * 3 and *17) were determined. An association between the carriaae of the C/C aenotype in rs2305948 and a 2 decrease in alomerular filtration rate (x2 = 4.185, p = 0.032) were found. Additionally, the C/C aenotype in rs2305948 was associated with hiaher blood pressure (x2 = 12.593, p = 0.001). For men, we identified a positive correlation between the rs2305948 C/C allele and the number of sianificant coronary stenoses (R = 0.227, p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }