Association of CHEK2 I157T polymorphism with the risk of ovarian border-line carcinomas in Russia
Автор: Sokolenko A.P., Lobeiko O.S., Krylova N.Yu., Maximov S.Ya., Urmancheyeva A.F., Matsko D.E., Nikonov A.A., Suspitsin E.N., Kuligina E.Sh., Iyevleva A.G., Ulibina Yu.M., Mitiushkina N.V., Rozanov M.E., Porhanova N.V., Szymanska-pasternak J., Lubinski J., Togo A.V., Imyanitov E.N.
Журнал: Сибирский онкологический журнал @siboncoj
Рубрика: Клинические исследования
Статья в выпуске: 4 (20), 2006 года.
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A Polish study has recently revealed an association between CHEK2 I157T polymorphism and an approximately 3-fold elevation of the risk of ovarian border-line carcinoma. The present study was aimed to validate this observation in the genetically similar population, i.e. Russian females. The frequency of the variant CHEK2 allele approached to 9/77 (11,7 %) in patients, but only 35/671 (5,2 %) in controls (р=0,022; OR=2,41 (1,03-5,48), that confirmed the role of genetic predisposition in the etiology of this rare ovarian disease.
Короткий адрес: https://sciup.org/14054333
IDR: 14054333
