Ассоциация полиморфизмов Ser447Ter гена LPL и rs9939609 гена FTO с ожирением у детей и подростков в популяции Ростова-на-Дону

Автор: Абд Али А.Х., Бочарова О.В., Шкурат Т.П., Шкурат М.А., Амелина М.А.

Журнал: Вестник Пермского университета. Серия: Биология @vestnik-psu-bio

Статья в выпуске: 2, 2021 года.

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Цель исследования - изучение ассоциации полиморфизмов Ser447Ter (C-G) гена LPL и rs9939609 гена FTO с ожирением у детей и подростков Ростовской обл. (Россия). В исследовании «случай-контроль» изучена взаимосвязь полиморфизмов rs9939609 гена FTO и Ser447Ter (S447X) гена LPL с ожирением у 520 детей и подростков обоего пола в возрасте от 3 до 18 лет: основную группу составили 370 детей и подростков с ожирением, а контрольную - 150 детей и подростков без ожирения. Генотипирование полиморфизмов выполнено с использованием ПЦР-аллель-специфичных праймеров. Полиморфизмы генов FTO (rs9939609) и LPL (Ser447Ter) в образцах донорской ДНК были типизированы электрофоретическим методом с применением коммерческих тест-систем компании «Литех» (Россия). Выявлена связь полиморфизма rs9939609 гена FTO с ожирением, установлены различия (р

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Lpl ser447ter, fto rs9939609, дети и подростки, ожирение

Короткий адрес: https://sciup.org/147235449

IDR: 147235449 | DOI: 10.17072/1994-9952-2021-2-119-127

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