Association of polymorphic variant RS 6746030 of the gene SCN9A with pain sensitivity in persons with addictive disorders

The study was devoted to investigation of interrelationship between polymorphic variant of the gene SCN9A (rs 6746030) and nociception parameters during formation of addictive disorders. Materials. 129 persons were examined: 50 patients with dependence on psychoactive substances (PAS), 29 persons from risk group, and 50 persons from control group. Methods. Thresholds of pain sensitivity and pain tolerance were identified with use of tensoalgometry method patented by us. Genotyping of polymorphic variant rs 6746030 of the gene SCN9A was performed by PCR method in real time with use of the competing TaqMan probes. Results. It was shown that in the group of women dependent on PAS, with the genotype AG rs 6746030 of the gene SCN9A, the tendency to increase in emotional perception of the upper pain threshold in comparison with carriers of GG genotype (5,5 (4,5- 6,5) and 6,0 (4,0-7,0), conventional units p=0,086) was found. The genotype AG rs 6746030 of the gene SCN9A and mutant variant of the allele A made a contribution to formation of addictive pathology at the stages of formation of dependence on PAS among females. Conclusion. The findings allowed assuming that the polymorphic variant rs 6746030 of the gene SCN9A could make a contribution to subjective perception of pain at different stages of formation of addictive pathology connected with change of indices of pain sensitivity.