Association of cardiorenal risk predictors in patients with different phenotypes of early disorders of carbohydrate metabolism

Objective: to identify associations between predictors of cardiorenal risk in patients with prediabetes and various phenotypes of early disorders of carbohydrate metabolism. Materials and Methods. A cross-sectional cohort study was conducted on a sample of 122 patients with prediabetes in Tyumen (mean age: 46.2±8.2 years). We studied the role of predictors of cardiovascular risk and early renal damage in the development of total cardiorenal events over the course of a year. The degree of association of parameters and conditions was assessed using odds ratios. Results. The most significant contributions to the development of concurrent early disorders of carbohydrate metabolism were made by impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), which were demonstrated by the quantitative insulin sensitivity check index (QUICKI) (p=0.036), as well as levels of interleukin 1 beta (IL-1β) (p=0.021), high-sensitivity C-reactive protein (hs-CRP) (p=0.031), urinary cystatin C (p=0.002) and C-peptide (p=0.039). The phenotype of patients with early disorders of carbohydrate metabolism (concurrent IFG and IGT) was characterized by a 1.5-fold increase in the risk of developing concurrent cardiorenal events. Conclusion. The combination of IFG and IGT in the group of patients with early disorders of carbohydrate metabolism demonstrates an increased risk of cardiorenal events, which requires a differentiated approach to the development of an algorithm for managing patients with different phenotypes of prediabetes.