Atherothrombotic and lacunar strokes in elderly patients: clinical manifestations and platelet haemostasis

Occurrence of ischemic stroke incidences increases with aging. The relations between platelets and endothelial cells are pivotal in pathogenesis of atherothrombotic and lacunar stroke, therefore, antiplatelet drugs’ administration is common for the purpose of prevention of secondary strokes. The goal of the study was to investigate clinical manifestation and platelet homeostasis parameters in elderly patients with atherothrombotic and lacunar strokes. 35 patients with stroke (66,3 ± 3,9 years) and 13 persons without stroke (63,6 ± 5,2) were examined. We performed routine clinical examination and laboratory investigation to reveal pathogenetic variants of stroke. Platelet homeostasis investigation: adenosindiphosphate-induced agregometry and flow-cytometry of receptor expression for fibrinogen; von Willebrand factor and P-selectin, and moleculargenetic test were carried out. Agregometry with stimulation by 2,5 and 5 mmol adenosindiphosphate revealed high reactive activity of platelets in a healthy group (85,3 ± 28,1% and 54,1 ± 20,0%, р