Atypical endometrial hyperplasia in the conception of tumor progression (literature review)

Introduction. In recent years there has been an frequency increase of endometrial hyperplasia in the structure of gynecological morbidity. Atypical endometrial hyperplasia represents important clinical relevance in the basis of progression to endometrial cancer. There are significant contradictions in the interpretation of endometrial hyperplasia in modern classifications, which are differ from the data provided in ICD-10. The aim of the study. This review aims to analyze the modern interpretation of endometrial hyperplasia in the concept of tumor progression. Materials and methods. The analysis of PubMed, Embase, Cochrain databases was performed, and the latest publications on the problem of GE with an emphasis on AGE were studied using the keyword "atypical endometrial hyperplasia". Results. The study presents a morphological classification of endometrial hyperplasia and shows a modern understanding of the progression of different nosological forms of this pathology. It is noted that endometrial hyperplasia is a clinical and morphological diagnosis based on anamnestic data, complex clinical and instrumental research and competent interpretation of morphological results. Conclusion. Morphological analysis is the most precise method for diagnosing different types of endometrial hyperplasia, provided that the surgical material is collected correctly. The histological structure and changes at the cellular level are assessed Only on the basis of a comprehensive assessment is a final morphological conclusion made about the nature of the diagnosed pathological process. Perfect interpretation of histological material requires a highly qualified morphologist, as well as the availability of modern laboratory equipment.