B-endorphine and selective agonists of opiate receptors in regulation of lymphocyte proliferative response. Role of opiate receptor blockade

It was determined that ??-endorphine, DAGO and DADLE in vitro system exerted promoting effect on lymphocyte functional activity in presence of PHA 2,5 ??g/ml. Their effect was intensified under the introduction of non-selective antagonist naloxone hydrochloride into cultures. Selective ??-inhibitor of naltrindol hydrochloride abolished the effects of ??-endorphine and selective ??-agonist DAGO.