Beta3-adrenоreceptors of the myocardium (review)

The paper provides information about the presence of beta3- adrenоceptors (ARs) in the myocardium of humans and animals. Their activation causes negative inotropic, chronotropic and lusitropic effects, and counteracts the development of myocardial hypertrophy. Underlying all of these effects is the activation of NO- synthase way. Beta3-AR activation prevents the development of heart failure (by reducing the damaging effect of high concentrations of catecholamines), but can also cause the development of acute heart failure, which is especially likely in patients of cardiological profile with the constant reception of beta1-AR and beta2- AR blockers. The question of the possibility relief of such state with the use of mildronate and other exogenous sensitizers of beta1-AR and beta2-AR is discussed.