Biochemical aspects of reconstructive operations on the aortic arch under deep hypothermic circulatory arrest with retrograde cerebral perfusion

In the group of patients were operated on aortic arch under hypothermic circulatory arrest and retrograde cerebral perfusion, the specifics of carbohydrate, lipid metabolism and lipid peroxidation were studied. It was found that perfusion cooling is accompanied by hyperglycemia activation of glycolysis and 55 lipolytic processes. Utilization of glucose by the brain is reduced during deep hypothermia and restored by the end of operation (120 minutes after cardiopulmonary bypass). Activation of lipid peroxidation starts at the stage of perfusion cooling and achieves maximum during reperfusion. The damaging effect of LPO is opposite by the activation of the antioxidant system. Normalization of metabolism and lipid peroxidation occurs by the third day after surgery.