Blood biochemical parameters in the assessment of the body conditions under the induced subhepatic cholestasis in rats

Blood biochemical parameters as possible markers of the body conditions under the subhepatic holestasis have been studied. The parameters have been recorded at 7th, 9th, 15th, 25th and 50th sec. of the experiment to reveal their role in the tuning of the rat’s organism. The elevated activity of alanine aminotransferase and the acidic phosphatase in the blood from 7th till 25th days of experiments can serve as markers of the subhepatic cholestasis under the elevated level of the bilirubin (expecially, its indirect fraction). Certain compensation of the metabolic disorders is recorded starting from 25th day of experiment. Although the complete remission was been observed, the partial one can be explained by the recanalization of the choledochus ducts.