Biological dosimetry by chromosome analysis
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In the work, based on the analysis of literature data, the information content and accuracy of cytogenetic methods for determining the absorbed doses of ionizing radiation are evaluated. It is concluded that the range of doses that can be determined using chromosomal analysis is between 0.2-0.3 and 6-8 Gy in the case of acute x-ray or γ-irradiation. An accurate dose assessment can be performed within three months after irradiation. The frequency of unstable type of aberrations (dicentrics and rings) drops rapidly over two years and it is difficult to record them after that. Theoretically, doses can be estimated by analyzing stable-type aberrations (translocation) using the special staining method (FISH-method) in the case of irradiation more than two years ago or chronic irradiation. The necessity of introducing automated cytogenetic analysis systems is emphasized, since counting aberrations at doses below 0.2–0.3 Gy requires a considerable amount of work. It is also necessary to define a standard dose-response curve for the FISH method.
Короткий адрес: https://sciup.org/170170354
IDR: 170170354
Список литературы Biological dosimetry by chromosome analysis
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