Biological and clinical-social mechanisms of development of schizophrenia (results of complex theme of research work of Mental Health Research Institute SB RAMSCI, 2009—2012)

Mental Health Research Institute SB RAMSci. 634014, Tomsk, Aleutskaya Street, 4. Study of molecular-genetic, psychoneu-roimmunological and metabolic mechanisms of clinical dynamic and formation of social adaptation of patients with endogenous mental diseases has ben conducted. Role of proteins of kinase family in pathophysiological processes in schizophrenia has been studied. Concept of imbalance of Th1/Th2 factors of the immune protection with study of polymorphism of cytokine genes has been developed. Peculiarities of psychoneuroimmu-nomodulation in clinical dynamic and formation of variants of social adaptation in endogenous disorders have been identified. Influence of long therapy of schizophrenic patients with atypical neuroleptics on system of the immunity has been studied. Methods of pathogenetic diagnosis of disturbances of adaptation, ways of therapy and rehabilitation of patients with endogenous mental disorders have been developed.