Биология суицидальности. Близнецы и суициды

Автор: Козлов В.А., Голенков А.В.

Статья в выпуске: 4 (53) т.14, 2023 года.

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Собраны и проанализированы находящиеся в свободном доступе сведения в базе данных PubMed о суицидальном поведении близнецов. В обзоре литературы данные стратифицированы в тематические разделы о сложностях определения наследуемости при оценке суицидальности близнецов, предикторах их суицидального поведения, анализ и сопоставление реестровых исследований суицидального поведения и его ассоциациях с генетическими факторами, половой стратификации суицидального поведения, суицидальном поведении у близнецов с психическими расстройствами, результатах исследований генных ассоциаций типа случай контроль и полногеномных исследований их суицидальности. Рассмотрены генетические и эпигенетические причины дискордантности монозиготных близнецов. Сформированный к настоящему времени пул исследований позволяет сделать вывод, что суицидальное поведение у близнецов наследуемо и рано проявляет себя комплексом вербальных поведенческих предикторов. Базовой основой формирования суицидального поведения является накопление в геноме однонуклеотидных полиморфизмов, экспрессия которых ассоциирована с формированием личности и таких её черт, как повышенная агрессивность, гиперактивность, расстройство внимания. Суицидальное поведение и явные психические расстройства (биполярная депрессия, шизофрения) коморбидны, но в целом не ассоциированы.

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Суицидальное поведение, психические расстройства, близнецы, монозиготы, дизиготы, наследственность, геном

Короткий адрес: https://sciup.org/140303357

IDR: 140303357 | DOI: 10.32878/suiciderus.23-14-04(53)-3-38

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