Bioplastic сollagen material Collost in treatment of patients with diabetic foot syndrome (multicenter study)

Objective: to evaluate the efficacy of collagen material in patients with diabetic foot syndrome.Materials and methods. 71 patients with diabetic foot syndrome of varying severity were included in the multicenter study. Patients were randomized into two homogeneous groups. In the control group patients (n=35) received the standard therapy, 36 patients (main group) additionally used the collagenous biomaterial "Collost".Results. Implication of biomaterial "Collost" led to more rapid and effective healing of the ulcer, the wound area decreased mainly due to a more rapid regression of its width, while the treatment success increased by 1.7 times. The additional use of a collagen biomaterial led to the increase in the incidence of complete epithelialization from 8.6% to 22.2% despite the reduction in the incidence of unsuccessful treatment from 34.3% to 8.3%. Correlation analysis showed that a favorable outcome, that reflected in the good or complete healing of wound with background of small size of the defect, Wagner II without expressed signs of infection and ischemia, and also with use of collagen material. The outcome was associated with background of low levels of red blood cells, segmented neutrophils, protein, high level of lymphocytes, it is deteriorated in proportion to the stage and extent of injury, recurrence of DFS, amputations.