Blebbing of the plasma membrane of lymphocytes in the postoperative period of urolithiasis

Urolithiasis is an urgent problem of surgical urology, about 200 thousand operations are performed annually in the Russian Federation. The complicated course of the postoperative period is accompanied by changes in homeostasis associated with immune activation and dysregulation of the endothelial system. The study evaluated the parameters of lymphocyte plasma membrane blebbing in patients with complicated and uncomplicated postoperative urolithiasis. 240 patients suffering from urolithiasis took part, who underwent surgical treatment. Patients were divided into two clinical groups: I clinical group (n = 130) - patients with a favorable course of the postoperative period of urolithiasis, II clinical group (n = 110) - patients with a complicated course of the postoperative period of urolithiasis. The control group was - 25 practically healthy persons. Lymphocyte membrane status was assessed by phase contrast microscopy. The maximum frequency of plasma membrane changes was recorded in patients with postoperative complications and amounted to 15.92 [13.20; 17.01] when evaluating initial blebbing and 21.93 [17.67; 30.45] for terminal blebbing. With a favorable course of postoperative period, patients with urolithiasis did not have statistically significant changes in the parameters of blebbing of the plasma membrane of lymphocytes.