C1Q nephropathy (clinical case)

C1q nephropathy rare, it is not well studied pathology characterized by deposition of C1q component of complement and immune complexes in the mesangium. The diagnosis requires a kidney biopsy with the study of immune complexes. With light microscopy, this pathology manifests itself as a disease of minimal changes disease (MCD), focal segmental glomerulosclerosis (FSGS), and proliferative glomerulonephritis. The clinical picture is diverse, fluctuating from asymptomatic hematuria or proteinuria to nephrotic syndrome. Corticosteroids are the basis of treatment, and immunosuppressive agents are reserved for steroid-resistant cases. The presence of nephrotic syndrome and FSGS predict unfavorable outcomes, unlike the favorable outcomes in patients with MCD. In this article, we describe the clinical case, histopathology, the clinical feature of C1q nephropathy.