Циркулирующие опухолевые клетки (ЦОК) при раке молочной железы: прогностическая значимость и методы выделения

Циркулирующие опухолевые клетки (ЦОК) при раке молочной железы: прогностическая значимость и методы выделения

Автор: Зубцов Дмитрий Александрович, Зубцова Жанна Исхаковна, Лавров Александр Вячеславович, Легченко Екатерина Вячеславовна, Аладинский Владимир Александрович, Потеряхина Анастасия Валерьевна, Гольдштейн Дмитрий Вадимович

Журнал: Труды Московского физико-технического института @trudy-mipt

Рубрика: Молекулярная и биологическая физика

Статья в выпуске: 3 (15) т.4, 2012 года.

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Существуют различные методы обнаружения циркулирующих опухолевых клеток в крови больных. Проведен анализ литературы, дана оценка преимуществ каждой из применяемых технологий. Основным показателем оценки являлись чувствительность и специфичность метода определения ЦОК. Для изучения оценки прогностической значимости определения опухолевых клеток в крови пациентов были изучены научные работы в базах Pubmed и eLibrary, а также работы из списков цитирования ключевых обзорных статей по данной теме.

Циркулирующие опухолевые клетки, диссеминированные опухолевые клетки, рак молочной железы, прогноз заболевания, диагноз, полимеразная цепная реакция в реальном времени

Короткий адрес: https://sciup.org/142185845

IDR: 142185845

Список литературы Циркулирующие опухолевые клетки (ЦОК) при раке молочной железы: прогностическая значимость и методы выделения

  • Siegel R., Naishadham D., Jemal A. Cancer Statistics//Cancer J. -2012. -P. 10-29.
  • Осинский С. П., Глузман Д. Ф. Диссеминированные опухолевые клетки в крови и кост-ном мозге (Молекулярный прогноз в клинической онкологии)//Онкология. -2006. -T. 8 -С. 102-108.
  • Красильников С. Э., Сидоров С. В., Гуляева Л. Ф. Cравнительный анализ экспрессии генов ER𝛼 и ароматазы в опухолевых тканях молочной железы и эндометрия//Сибирский онкологический журнал. -2007. -T. 4 -С. 89-95.
  • Ashworth T. R. A case of cancer in which cells similar to those in the tumours were seen in the blood after death//Aust. Med. J. -1869. -V. 14. -P. 146-149.
  • Ignatiadis M., Xenidis N., Perraki M., Apostolaki S., Politaki E., Kafousi M., Stathopoulos E. Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer//Journal of clinical oncology: official journal of the American Society of Clinical Oncology. -2007. -V. 25, N 16. -P. 5194-5202.
  • Stathopoulou A., Vlachonikolis I., Mavroudis D., Perraki M., Kouroussis C., Apostolaki S., Malamos N. Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance//Journal of clinical oncology: official journal of the American Society of Clinical Oncology. -2002. -V. 20, N 16. -P. 3404-3412.
  • Xenidis N., Perraki M., Kafousi M., Apostolaki S., Bolonaki I., Stathopoulou A., Kalbakis K. Predictive and prognostic value of peripheral blood cytokeratin-19 mRNA-positive cells detected by real-time polymerase chain reaction in node-negative breast cancer patients//Journal of clinical oncology: official journal of the American Society of Clinical Oncology. -2006. -V. 24, N 23. -P. 3756-3762.
  • Braun S., Pantel K., Muller P., Janni W., Hepp F., Kentenich C. Cytokeratin-Positive Cells in the Bone Marrow and Survival of Patients with Stage I, II, or III Breast Cancer//New England journal of medicine. -2000. -V. 343, N 4. -P. 525-533.
  • Braun S., Vogl F., Naume B., Janni W., Osborne M., Coombes R., Schlimok G. A pooled analysis of bone marrow micrometastasis in breast cancer//New England journal of medicine. -2005. -V. 353, N 8. -P. 793-802.
  • Diel I., Kaufmann M., Costa S., Minckwitz G., Solomayer E., Kaul S., Bastert G. Micrometastatic Breast Cancer Cells in Bone Comparison With Nodal Status//Journal of the National Cancer Institute. -1996. -V. 88, N 22. -P. 1652-1658.
  • Pierga J., Bonneton C., Vincent-Salomon A., de Cremoux P., Nos C., Blin N., Pouillart P. Clinical significance of immunocytochemical detection of tumor cells using digital microscopy in peripheral blood and bone marrow of breast cancer patients//Clinical cancer research: an official journal of the American Association for Cancer Research. -2004. -V. 10, N 4. -P. 1392-1400.
  • Pantel K., Muller V., Auer M., Nusser N., Harbeck N., Braun S. Detection and clinical implications of early systemic tumor cell dissemination in breast cancer//Clinical cancer research. -2003. -V. 9, N 17. -P. 6326-6334.
  • Vona G., Sabile A., Louha M., Sitruk V., Romana S., Schutze K., Capron F. Isolation by size of epithelial tumor cells?: a new method for the immunomorphological and molecular characterization of circulatingtumor cells//The American journal of pathology. -2000. -V. 156, N 1. -P. 57-63.
  • Nagrath S., Sequist L., Maheswaran S., Bell D., Irimia D., Ulkus L., Smith M. Isolation of rare circulating tumour cells in cancer patients by microchip technology//Nature. -2007. -V. 450, N 7173. -P. 1235-1239.
  • Tveito S., Andersen K., Karesen R., Fodstad O. Analysis of EpCAM positive cells isolated from sentinel lymph nodes of breast cancer patients identifies subpopulations of cells with distinct transcription profiles//Breast cancer research. -2008. -V. 13, N 4. -P. 75.
  • Ignatiadis M., Kallergi G., Ntoulia M., Perraki M., Apostolaki S., Kafousi M., Chlouverakis G. Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer//Clinical cancer research: an official journal of the American Association for Cancer Research. -2008. -V. 14, N 9. -P. 2593-2600.
  • Xenidis N., Ignatiadis M., Apostolaki S., Perraki M., Kalbakis K., Agelaki S., Stathopoulos E. Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer//Journal of clinical oncology: official journal of the American Society of Clinical Oncology. -2009. -V. 27, N 13. -P. 2177-2184.
  • Mikhitarian K., Martin R., Ruppel M., Gillanders W., Hoda R., Schutte D., Callahan K. Detection of mammaglobin mRNA in peripheral blood is associated with high grade breast cancer: interim results of a prospective cohort study//BMC cancer. -2008. -V. 8. -P. 55.
  • Ferro P., Franceschini M., Bacigalupo B., Dessanti P., Falco E., Fontana V., Gianquinto D. Detection of circulating tumour cells in breast cancer patients using human mammaglobin RT-PCR: association with clinical prognostic factors//Anticancer research. -2010. -V. 30, N 6. -P. 2377-2382.
  • Suchy B., Austrup F., Driesel G., Eder C., Kusiak I., Uciechowski P., Grill H. Detection of mammaglobin expressing cells in blood of breast cancer patients//Cancer letters. -2000. -V. 158, N 2. -P. 171-178.
  • Watson M. A., Fleming T. P., Flemine T. P. Mammaglobin, a Mammary-specific Member of the Uteroglobin Gene Family, Is Overexpressed in Human Breast Cancer Mammaglobin, a Mammary-specific Member of the Uteroglobin Gene Family «Is Overexpressed in Human Breast Cancer»//Cancer Research. -1996. -P. 860-865.
  • Ge Y., Domschke C., Stoiber N., Schott S., Heil J., Rom J., Blumenstein M. Detronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome//Cancer immunology, immunotherapy. -2011.
  • Krivacic R., Ladanyi A., Curry D., Hsieh H., Kuhn P., Bergsrud D., Kepros J. A rare-cell detector for cancer//PProceedings of the National Academy of Sciences of the United States of America. -2004. -V. 101, N 29. -P. 10501-10504.
  • Thurm H., Ebel S., Kentenich C., Hemsen A., Riethdorf S., Coith C., Wallwiener D. Rare expression of epithelial cell adhesion molecule on residual micrometastatic breast cancer cells after adjuvant chemotherapy//Clinical cancer research: an official journal of the American Association for Cancer Research. -2003. -V. 9, N 7. -P. 2598-2604.
  • Braun S., Hepp F., Sommer H., Pantel K. Tumor-antigen heterogeneity of disseminated breast cancer cells: implications for immunotherapy of minimal residual disease//Int. journal of cancer. -1999. -V. 84, N 1. -P. 1-5.
  • Sleijfer S., Gratama J., Sieuwerts A., Kraan J., Martens J., Foekens J. Circulating tumour cell detection on its way to routine diagnostic implementation?//European journal of cancer (Oxford, England: 1990). -2007. -V. 43, N 18. -P. 2645-2650.
  • Ntouroupi T., Ashraf S., McGregor S., Turney B., Seppo A., Kim Y., Wang X. Detection of circulating tumour cells in peripheral blood with an automated scanning fluorescence microscope//British journal of cancer. -2008. -V. 99, N 5. -P. 789-795.
  • Fehm T., Krawczyk N., Solomayer E., Becker-Pergola G., Durr-Storzer S., Neubauer H., Seeger H. ER𝛼 -status of disseminated tumour cells in bone marrow of primary breast cancer patients//Breast cancer research. -2008. -V. 10, N 5. -P. 76.
  • Theodoropoulos P., Polioudaki H., Agelaki S., Kallergi G., Saridaki Z., Mavroudis D., Georgoulias V. Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer//Cancer letters. -2010. -V. 288, N 1. -P. 99-106.
  • Patel A., Allen J., Dicker D., Peters K., Jonas M., Glantz M., El-deiry W. Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases//Current. -2011. -P. 1-9.
  • Camara O., Jorke C., Hammer U., Egbe A., Rabenstein C., Runnebaum I., Hoeffken K. Monitoring circulating epithelial tumour cells (CETC) to gauge therapy: in patients with disease progression after trastuzumab persisting CETC can be eliminated by combined lapatinib treatment//Journal of cancer research and clinical oncology. -2009. -V. 135, N 4. -P. 643-647.
  • Andreopoulou E., Yang L.-Y., Rangel K., Reuben J., Hsu L., Krishnamurthy S., Valero V. Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/DetectTM versus Veridex CellSearchTM system//Int. journal of cancer. -2012.-V. 130, N 7. -P. 1590-1597.
  • Kagan M., Howard D., Bendele T., Mayes J., Silvia J., Repollet M., Doyle J. A Sample Preparation and Analysis System for Identification of Circulating Tumor Cells//Journal of Clinical Ligand Assay. -2002. -V. 25, N 1. -P. 104-110.
  • Bauer K., de la Torre-Bueno J., Diel I., Hawes D., Decker W., Priddy C., Bossy B. Reliable and sensitive analysis of occult bone marrow metastases using automated cellular imaging//Clinical cancer research: an official journal of the American Association for Cancer Research. -2000. -V. 6, N 9. -P. 3552-3559.
  • Kraeft S., Sutherland R., Gravelin L., Hu G., Ferland L., Richardson P., Elias A. Detection and analysis of cancer cells in blood and bone marrow using a rare event imaging system//Clinical cancer research: an official journal of the American Association for Cancer Research. -2000. -V. 6, N 2. -P. 434-442.
  • Negin B., Cohen S. Circulating tumor cells in colorectal cancer: past, present, and future challenges//Current treatment options in oncology. -2010. -V. 11, N 1-2. -P. 1-13.
  • Van der Auwera I., Peeters D., Benoy I., Elst H., Van Laere S., Prove A., Maes H. Circulating tumour cell detection: a direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT-PCR in patients with metastatic breast cancer//British journal of cancer. -2010. -V. 102, N 2. -P. 276-284.
  • Deng G., Herrler M., Burgess D., Manna E., Krag D., Burke J. Enrichment with anticytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients//Breast cancer res. -2008. -V. 10, N 4. -P. 69.
  • Tan S., Yobas L., Lee G., Ong C., Lim C. Microdevice for the isolation and enumeration of cancer cells from blood//Biomedical microdevices. -2009. -V. 11, N 4. -P. 883-892.
  • Gertler R., Rosenberg R., Fuehrer K., Dahm M., Nekarda H., Siewert J. Detection of circulating tumor cells in blood using an optimized density gradient centrifugation//Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. -2003. -V. 162. -P. 149-155.
  • Busch R., Cesar D., Higuera-Alhino D., Gee T., Hellerstein M., McCune J. Isolation of peripheral blood CD4(+) T cells using RosetteSep and MACS for studies of DNA turnover by deuterium labeling//J. of immunological methods. -2004. -V. 286, N 1-2. -P. 97-109.
  • Hayes G., Busch R., Voogt J., Siah I., Gee T., Hellerstein M., Chiorazzi N. Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: validation of a simplified method suitable for multi-center clinical studies//Leukemia research. -2010. -V. 34, N 6. -P. 809-815.
  • Cohen S., Punt C., Iannotti N., Saidman B., Sabbath K., Gabrail N., Picus J. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer//Journal of clinical oncology: official journal of the American Society of Clinical Oncology. -2008. -V. 26, N 19. -P. 3213-3221.
  • Nezos A., Pissimisis N., Lembessis P., Sourla A., Dimopoulos P., Dimopoulos T., Tzelepis K. Detection of circulating tumor cells in bladder cancer patients//Cancer treatment reviews. -2009. -V. 35, N 3. -P. 272-279.
  • Tewes M., Aktas B., Welt A., Mueller S., Hauch S., Kimmig R., Kasimir-Bauer S. Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: an option for monitoring response to breast cancer related therapies.//Breast cancer research and treatment. -2009. -V. 115, N 3. -P. 581-590.
  • Cristofanilli M. The biological information obtainable from circulating tumor cells//Breast (Edinburgh, Scotland). -2009. -V. 18, N 3. -P. 38-40.
  • Sun Y.-F., Yang X.-R., Zhou J., Qiu S.-J., Fan J., Xu Y. Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance//Journal of cancer research and clinical oncology. -2011. -P. 1151-1173.
  • Hayashi N., Yamauchi H. Role of circulating tumor cells and disseminated tumor cells in primary breast cancer//Breast cancer (Tokyo, Japan). -2011. -P. 1-5.
  • Aktas B., Tewes M., Fehm T., Hauch S., Kimmig R., Kasimir-Bauer S. Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor Marques A., Teixeira E., Diamond J., Correia H., Santos S., Neto L., Ribeiro M. Detection of human mammaglobin mRNA in serial peripheral blood samples from patients with nonmetastatic breast cancer is not predictive of disease recurrence//Breast cancer res. and treatment. -2009. -V. 114, N 2. -P. 223-232.
  • Schmitt M., Foekens J. Circulating tumor cells in blood of primary breast cancer patients assessed by a novel RT-PCR test kit and comparison with status of bone marrowdisseminated tumor cells//Breast cancer research. -2009.-V. 11, N 5. -P. 109.
  • Fehm T., Hoffmann O., Aktas B., Becker S., Solomayer E., Wallwiener D., Kimmig R. Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells//Breast cancer res. -2009. -V. 11, N 4. -P. 59.
  • Lacroix M. Significance, detection and markers of disseminated breast cancer cells//Endocrine-related cancer. -2006. -V. 13, N 4. -P. 1033-1067.
  • Pantel K., Cote R., Fodstad O. Detection and clinical importance of micrometastatic disease//Journal of the National Cancer Institute. -1999. -V. 91, N 13. -P. 1113-1124.
  • Ring A., Smith I., Dowsett M. Reviews Circulating tumour cells in breast cancer//Lancet Oncology. -2004.-V. 5, N 2. -P. 79-88.
  • Jung R., Kruger W., Hosch S., Holweg M., Kroger N., Gutensohn K., Wagener C. Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo and in vitro//British journal of cancer. -1998. -V. 78, N 9. -P. 1194-1198.
  • Zippelius A., Kufer P., Honold G., Kollermann M. W., Oberneder R., Schlimok G., Riethmuller G. Limitations of reverse-transcriptase polymerase chain reaction analyses for detection of micrometastatic epithelial cancer cells in bone marrow//Journal of clinical oncology: official journal of the American Society of Clinical Oncology. -1997. -V. 15, N 7. -P. 2701-2708.
  • Kowalewska M., Chechlinska M., Markowicz S., Kober P., Nowak R. The relevance of RTPCR detection of disseminated tumour cells is hampered by the expression of markers regarded as tumour-specific in activated lymphocytes//European journal of cancer (Oxford, England). -2006. -V. 42, N 16. -P. 2671-2674.
  • Fehm T., Muller V., Alix-Panabieres C., Pantel K. Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance//Breast cancer res. -2008. -V. 10, N 1. -P. 1.
  • Daskalaki A., Agelaki S., Perraki M., Apostolaki S., Xenidis N., Stathopoulos E., Kontopodis E. Detection of cytokeratin-19 mRNA-positive cells in the peripheral blood and bone marrow of patients with operable breast cancer//British journal of cancer. -2009. -V. 101, N 4. -P. 589-597.
  • Fehm T., Muller V., Aktas B., Janni W., Schneeweiss A., Stickeler E., Lattrich C. HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial//Breast cancer res. and treatment. -2010. -V. 124, N 2. -P. 403-412.
  • Hayashi N., Nakamura S., Tokuda Y., Shimoda Y., Yagata H., Yoshida A., Ota H. Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer//Int. journal of clinical oncology/Japan Society of Clinical Oncology. -2011.
  • Marques A., Teixeira E., Diamond J., Correia H., Santos S., Neto L., Ribeiro M. Detection of human mammaglobin mRNA in serial peripheral blood samples from patients with nonmetastatic breast cancer is not predictive of disease recurrence//Breast cancer res. and treatment. -2009. -V. 114, N 2. -P. 223-232.
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