Cytogenetic effects soluble form of hypericin in deficient antioxidant protection individual drosophila melanogaster

An assessment of the influence of water-soluble forms of hypericin in different concentrations on the frequency of DNA damage in neuroblasts of the sod mutant individuals Drosophila melanogaster, with disturbances in antioxidant defense (on Cu/ZnSod, MnSod isoenzyme) and wild-type flies Canton-S with the light and dark activation. Introduction to the culture medium of hypericin leads to an increase in larval neuroblasts level of DNA damage. Genotoxic effects at the light activation of hypericin most pronounced in the Sod -mutants. For normal individuals the phenotype revealed dose of hypericin (1 µM) in which the frequency of DNA breaks below the control. The strong dependence of the biological effectiveness of a hydrophilic hypericin on its concentration, the genotype animals and lighting conditions was established. It is assumed that the studied form of hypericin may exhibit antioxidant activity mainly through MnSod-activation.