Comparative Analysis and Ensemble Optimization of CNN Architectures for MRI-Based Brain Tumor Diagnosis

Brain tumor detection and classification from MRI images is a challenging task. Early and accurate diagnosis are essential for selecting appropriate treatment plans and improving patient outcomes. Despite significant advances in deep learning for medical image recognition, comprehensive comparative analyses of brain tumor classification models, particularly regarding ensemble optimization, remain limited. This paper uses four state-of-the-art deep learning frameworks, namely EfficientNetB4, MobileNetV3, MobileNetV2, and EfficientNetB0, to classify brain MRI images into four categories: Glioma, Meningioma, Pituitary tumor, and Normal. It employs a two-phase transfer learning approach, followed by 5-fold cross-validation on 875 MRI images. A unified experimental framework is employed, incorporating a two-phase transfer learning approach, consistent preprocessing, and a rigorous evaluation protocol with 5-fold cross-validation and an independent test set to prevent data leakage. Both full and selective ensemble strategies are examined to improve the robustness and stability. The models are evaluated using accuracy, precision, recall, F-1 score, confusion matrices, and accuracy curves, and statistical validation using McNemar’s test. MobileNetV3 achieves the highest test accuracy of 98.76%, followed by EfficientNetB4 (97.89%) and EfficientNetB0 (93.48%). MobileNetV2 performs significantly worse, with an accuracy of less than 80%. The selective ensemble technique (which uses the best models) attains the highest accuracy of 92.97%, compared to the full ensemble (84.40%), which improves prediction robustness but does not surpass the best individual model in peak accuracy. Overall, it can be concluded that MobileNetV3 is the most suitable architecture for brain tumor classification, delivering high accuracy with minimal computational complexity. The selective ensemble approach also enhances performance, maintaining computational efficiency, emphasizing the importance of informed model selection in neuro-oncological image analysis and clinical decision-support systems.