Comparison of nonshivering thermogenesis induced by norepinephrine stress in tree shrews
Автор: Zhu Wan-Long, Zhang Di, Zheng Jia, Zhang Lin, Liu Jin-Hu, Cheng Jin, Wang Zheng-Kun
Журнал: Журнал стресс-физиологии и биохимии @jspb
Статья в выпуске: 4 т.9, 2013 года.
Бесплатный доступ
Nonshivering thermogenesis (NST)is an important thermogenic mechanism for small mammals. Quantitative measurement of NST is usually stimulated by injection of norepinephrine. The injection dosage of norepinephrine (NE)is critical for eliciting the maximum NST. Three empirical equations of NE dosages were often referenced in previous studies: (1)NE (mg / kg)= 2.53W -0.4; (2)NE(mg/kg) = 3.3W -0.458 and (3)NE(mg/kg)= 6.6W -0.458. In the present study, we used tree shrews ( Tupaia belangeri ) as experiment subjects to test the effects of the three dosages of NE on NST. Results showed that all the three dosages of NE could induce the maximum NST for T. belangeri. No significant differences were found in NST among groups and the NST was respectively 2.63±0.12 (formula 1), 2.66±0. 11 (formula 2) and 2.78±0.15 (formula 3). However, when injected with NE dosage from formula 3, the increase of body temperatures was significantly higher than the other two NE dosages (increased 1.5±0. 1 oC (formula 3), 0.8±0. 2 oC (formula 2), and 0.6±0. 1 oC (formula 1), respectively). In order to prevent the death because of hyperthermia, formula 1 or 2 is recommended to be used.
Tupaia belangeri, nonshivering thermogenesis, norepinephrine
Короткий адрес: https://sciup.org/14323799
IDR: 14323799
Список литературы Comparison of nonshivering thermogenesis induced by norepinephrine stress in tree shrews
- Depocas, F. (1960) The calorigenic response of cold-acclimated white rats to infused noradrenaline. Can J Biochem Physiol, 38: 107-114
- Jansky, L. (1973) Non-shivering thermogenesis and its thermoregulatory significance. Biol Rev, 48: 85-132
- Heldmaier, G. (1971) Nonshivering thermogenesis and body size in mammals. J Comp Physiol, 73: 222-248
- Heldmaier, G., Steinlechner, S., Rafael, J. (1982) Nonshivering thermogenesis and cold resistance during seasonal acclimatization in the Djungarian hamster. J Comp Physiol B, 149: 1-9
- Hill, R.W. (1972) Determination of oxygen consumption by use of the paramagnetic oxygen analyzer. J Appl. Physiol., 33(2): 261-263
- Klingenberg, M., Echtay, K.S. (2001) Uncoupling proteins: the issues from a biochemist point of view. Biochim Biophys Acta, 1504: 128-143
- Li, Q.F., Sun, R.Y., Huang, C.X., Wang, Z.K., Liu, X.T., Hou, J.J. (2001) Cold adaptive thermogenesis in small mammals from different geographical zones of China. Comp Biochem Physiol, 129: 949-961
- Li, X.S., Wang, D.H. (2005) Regulation of body weight and thermogenesis in seasonally acclimatized Brandt’s voles (Microtus brandti). Homones and Behavior, 48(3): 321-328
- Merritt, J. (1986) Winter survival adaptations of the short-tailed shrew (Blarina brevicauda) in an Appalachian montane forest. J Mammal, 67: 450-464
- Wang, Y.X., Li, C.Y., Ma, S.L. (1991) The classification and ecology of tree shrews. In: Peng, Y., Ye, Z., Zou, R. Eds. Biology of Chinese Tree shrews (Tupaia belangeri Chinensis). Yunnan Scientic and Technological Press, Kunming
- Wang, J.M., Wang, D.H. (2006) Comparison of nonshivering thermogenesis induced by dosages of norepinephrine from 3 allometric equations in Brandt' s voles (Lasiopodomys brandtii). Acta Theriol. Sin., 26(1): 84-88
- Wunder, B.A., Gettinger, R.D. (1996) Effects of body mass and temperature acclimation on the nonshivering thermogenic response of small mammals. In: Geiser, F., Hulbert, A.J., Nicol, S.C. eds. Adaptations to the cold: Tenth international hibernation symposium, 131-139
- Zhang, L., Wang, R., Zhu, W., Liu, P., Cai, J., Wang, Z., Sivasakthivel, S., Lian, X. (2011) Adaptive thermogenesis of liver in tree shrew (Tupaia belangeri) during cold acclimation. Anim. Biol., 61: 385-401
- Zhang, L., Liu, P., Zhu, W., Cai, J., Wang, Z. (2012a) Variations in thermal physiology and energetics of the tree shrew (Tupaia belangeri) in response to cold acclimation. J. Comp. Physiol. B, 182: 167-176
- Zhang, L., Zhang, H., Zhu, W., Li, X., Wang, Z. (2012b) Energy metabolism, thermogenesis and body mass regulation in tree shrew (Tupaia belangeri) during subsequent cold and warm acclimation. Comp. Biochem. Physiol. A, 162: 437-442
- Zhang, L., Zhu, W.L., Wang, Z.K. (2012c) Role of photoperiod on hormone concentrations and adaptive capacity in tree shrews, Tupaia belangeri. Comp. Biochem. Physiol. A, 163: 253-259
- Zhu, W.L., Jia, T., Lian, X., Wang, Z.K. (2010) Effects of cold acclimation on body mass, serum leptin level, energy metabolism and thermognesis in Eothenomys miletus in Hengduan Mountains region. J. Therm. Biol., 35(1): 41-46
- Zhu, W.L., Zhang, H., Wang, Z.K. (2012). Seasonal changes in body mass and thermogenesis in tree shrews (Tupaia belangeri) the roles of photoperiod and cold. J. Therm. Biol., 37: 479-484
