Curcumin: a modulator of mammary malignancies

Curcumin: a modulator of mammary malignancies

Автор: Sachdeva Kanika, Kaur Jaskeerat

Журнал: Журнал стресс-физиологии и биохимии @jspb

Статья в выпуске: 3 т.20, 2024 года.

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Breast cancer is one of the leading causes of cancer-related deaths among females and accounts for around 25% of all female melanomas worldwide with increasing incidence every day. Among various natural phytochemicals studied against breast cancer, curcumin has been found to possess antioxidative properties with established safety record. Curcumin is a pleiotropic molecule possessing chemopreventive and chemotherapeutic properties. Curcumin arrests cancer formation at various stages ranging from transformation, proliferation as well as invasion. Transformation is arrested by constitutive de-activation of transcription factors like STAT 3, AP-1, NF-kB. Curcumin controls the expressions of oncogenes, growth factor like EGF, PGDF, FGF, decoy receptors, cyclin D1, survival factors that are important for tumoral cell proliferation. Curcumin successfully inhibits tumor metastasis by supressing the expression of matrix metalloproteinase, COX 2, adhesion molecules, Chemokines and TNF. Curcumin has revealed anticancerous effects in synergism with various compounds like piperine, genistein, mitomycin C, phosphatidicholine, monomethoxy polyethylene glycol, epigallocatechin gallate and metformin. Recent studies have attempted to study the efficacy of curcumin loaded nanoparticles as drug delivery system. This paper attempts to review the work on antitumoral effects of curcumin against breast cancer, underlying mechanisms and proposes further investigations that are needed for rational cancer therapy.

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Curcumin, breast cancer, anti-inflammatory, chemotherapeutic, chemopreventive, synergistic

Короткий адрес: https://sciup.org/143182797

IDR: 143182797

Список литературы Curcumin: a modulator of mammary malignancies

  • Aggarwal, B. B., & Sung, B. (2009). Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends in pharmacological sciences, 30(2), 85-94. Aggarwal, B. B., Bhatt, I. D., Ichikawa, H., Ahn, K. S.,
  • Sethi, G., Sandur, S. K.....& Shishodia, S. (2006). 10 Curcumin—biological and medicinal properties. In: Turmeric : the genus Curcuma, Editors: P.N. Ravindran, K. Nirmal Babu, and K. Sivaraman, pp. 298-368.
  • Aggarwal, B. B., Shishodia, S., Takada, Y., Banerjee, S., Newman, R. A., Bueso-Ramos, C. E., & Price, J. E. (2005). Curcumin suppresses the paclitaxel-induced nuclear factor-KB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clinical Cancer Research, 11(20), 7490-7498.
  • Bachmeier, B. E., Mohrenz, I. V., Mirisola, V., Schleicher, E., Romeo, F., Höhneke, C..... & Pfeffer, U. (2008). Curcumin downregulates the inflammatory cytokines CXCL1 and-2 in breast cancer cells via NFkB. Carcinogenesis, 29(4), 779789.
  • Bachmeier, B., Nerlich, A., lancu, C., Cilli, M., Schleicher, E., Vené, R..... & Pfeffer, U. (2007). The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice. Cellular physiology and biochemistry, 19(1-4), 137-152.
  • Bayet-Robert, M., Kwiatowski, F., Leheurteur, M., Gachon, F., Planchat, E., Abrial, C..... & Chollet, P. (2010). Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer biology & therapy, 9(1), 8-14.
  • Calaf, G. M., Echiburu-Chau, C., Wen, G., Balajee, A. S., & Roy, D. (2012). Effect of curcumin on irradiated and estrogen-transformed human breast cell lines. International journal of oncology, 40(2), 436-442.
  • Carroll, C. E., Ellersieck, M. R., & Hyder, S. M. (2008). Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells. Menopause, 15(3), 570-574.
  • Choudhuri, T., Pal, S., Agwarwal, M. L., Das, T., & Sa, G. (2002). Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS letters, 512(1-3), 334-340.
  • Chung, S. S., & Vadgama, J. V. (2015). Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFKB signaling. Anticancer research, 35(1), 39-46.
  • Ciolino, H. P., Daschner, P. J., Wang, T. T., & Yeh, G. C. (1998). Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochemical pharmacology, 56(2), 197-206.
  • De La Iglesia, N., Konopka, G., Puram, S. V., Chan, J. A., Bachoo, R. M., You, M. J..... & Bonni, A. (2008). Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes & development, 22(4), 449-462.
  • Divya, C. S., & Pillai, M. R. (2006). Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Molecular Carcinogenesis: Published in cooperation with the University of Texas MD Anderson Cancer Center, 45(5), 320-332.
  • Farajzadeh, R., Pilehvar-Soltanahmadi, Y., Dadashpour, M., Javidfar, S., Lotfi-Attari, J., Sadeghzadeh, H., ... & Zarghami, N. (2018). Nano-encapsulated metformin-curcumin in PLGA/PEG inhibits synergistically growth and hTERT gene expression in human breast cancer cells. Artificial cells, nanomedicine, and biotechnology, 46(5), 917-925.
  • Folkman, J. (2001). Angiogenesis-dependent diseases. In Seminars in oncology (Vol. 28, No. 6, pp. 536542). WB Saunders.
  • Holy, J. M. (2002). Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 518(1), 71-84.
  • Hua, W. F., Fu, Y. S., Liao, Y. J., Xia, W. J., Chen, Y. C., Zeng, Y. X.....& Xie, D. (2010). Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells. European journal of pharmacology, 637(1-3), 16-21.
  • Ibrahim, A., El-Meligy, A., Fetaih, H., Dessouki, A., Stoica, G., & Barhoumi, R. (2010). Effect of curcumin and Meriva on the lung metastasis of murine mammary gland adenocarcinoma. in vivo, 24(4), 401-408.
  • Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C..... & Wicha, M. S. (2010). Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast cancer research and treatment, 122, 777-785.
  • Kulkarni, S. J., Maske, K. N., Budre, M. P., & Mahajan, R. P. (2012). Extraction and purification of curcuminoids from Turmeric (Curcuma longa L.). International Journal of Pharmacology and Pharmaceutical Technology, 1(2), 81-84.
  • Lee, J., Kim, J. C., Lee, S. E., Quinley, C., Kim, H., Herdman, S..... & Raz, E. (2012). Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability. Journal of Biological Chemistry, 287(22), 18182-18189.
  • Liu, D., & Chen, Z. (2013). The effect of curcumin on breast cancer cells. Journal of breast cancer, 16(2), 133.
  • Liu, Q., Loo, W. T., Sze, S. C. W., & Tong, Y. (2009). Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkB, cyclinD and MMP-1 transcription. Phytomedicine, 16(10), 916-922.
  • Lv, Z. D., Liu, X. P., Zhao, W. J., Dong, Q., Li, F. N., Wang, H. B., & Kong, B. (2014). Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivo. International journal of clinical and experimental pathology, 7(6), 2818.
  • Marrogi, A., Pass, H. I., Khan, M., Metheny-Barlow, L. J., Harris, C. C., & Gerwin, B. I. (2000). Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. Cancer research, 60(14), 3696-3700.
  • Mehta, K., Pantazis, P., McQueen, T., & Aggarwal, B. B. (1997). Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anti-cancer drugs, 8(5), 470-481.
  • Musteanu, M., Blaas, L., Mair, M., Schlederer, M., Bilban, M., Tauber, S.....& Eferl, R. (2010). Stat3 is a negative regulator of intestinal tumor progression in ApcMin mice. Gastroenterology, 138(3), 1003-1011.
  • Plummer, S. M., Hill, K. A., Festing, M. F., Steward, W. P., Gescher, A. J., & Sharma, R. A. (2001). Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents. Cancer Epidemiology Biomarkers & Prevention, 10(12), 1295-1299.
  • Ramachandran, C., & You, W. (1999). Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin. Breast cancer research and treatment, 54, 269-278.
  • Ramachandran, C., Fonseca, H. B., Jhabvala, P., Escalon, E. A., & Melnick, S. J. (2002). Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer letters, 184(1), 1-6.
  • Ryan, J. L., Heckler, C. E., Ling, M., Katz, A., Williams, J. P., Pentland, A. P., & Morrow, G. R. (2013). Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiation research, 180(1), 34-43.
  • Sen, G. S., Mohanty, S., Hossain, D. M. S., Bhattacharyya, S., Banerjee, S., Chakraborty, J..... & Sa, G. (2011). Curcumin enhances the efficacy of chemotherapy by tailoring p65NFKB-p300 crosstalk in favor of p53-p300 in breast cancer. Journal of Biological Chemistry, 286(49), 42232-42247.
  • Shao, Z. M., Shen, Z. Z., Liu, C. H., Sartippour, M. R., Go, V. L., Heber, D., & Nguyen, M. (2002). Curcumin exerts multiple suppressive effects on human breast carcinoma cells. International journal of cancer, 98(2), 234-240.
  • Shao, Z. M., Shen, Z. Z., Liu, C. H., Sartippour, M. R., Go, V. L., Heber, D., & Nguyen, M. (2002). Curcumin exerts multiple suppressive effects on human breast carcinoma cells. International journal of cancer, 98(2), 234-240.
  • Siddique, Y. H., Ara, G., Beg, T., Gupta, J., & Afzal, M. (2010). Assessment of cell viability, lipid peroxidation and quantification of DNA fragmentation after the treatment of anticancerous drug mitomycin C and curcumin in cultured human blood lymphocytes. Experimental and toxicologic pathology, 62(5), 503-508.
  • Somasundaram, S., Edmund, N. A., Moore, D. T., Small, G. W., Shi, Y. Y., & Orlowski, R. Z. (2002). Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer research, 62(13), 3868-3875.
  • Somers-Edgar, T. J., Scandlyn, M. J., Stuart, E. C., Le Nedelec, M. J., Valentine, S. P., & Rosengren, R. J. (2008). The combination of epigallocatechin gallate and curcumin suppresses ERa-breast cancer cell growth in vitro and in vivo. International journal of cancer, 122(9), 1966-1971.
  • Soung, Y. H., & Chung, J. (2011). Curcumin inhibition of the functional interaction between integrin a6p4 and the epidermal growth factor receptor. Molecular cancer therapeutics, 10(5), 883-891.
  • Sun, S. H., Huang, H. C., Huang, C., & Lin, J. K. (2012). Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin. European journal of pharmacology, 690(1-3), 22-30.
  • Tabatabaei Mirakabad, F. S., Akbarzadeh, A., Milani, M., Zarghami, N., Taheri-Anganeh, M., Zeighamian, V., ... & Rahmati-Yamchi, M. (2016). A Comparison between the cytotoxic effects of pure curcumin and curcumin-loaded PLGA-PEG nanoparticles on the MCF-7 human breast cancer cell line. Artificial cells, nanomedicine, and biotechnology, 44(1), 423-430.
  • Tang, H., Murphy, C. J., Zhang, B., Shen, Y., Van Kirk, E. A., Murdoch, W. J., & Radosz, M. (2010). Curcumin polymers as anticancer conjugates. Biomaterials, 31(27), 7139-7149.
  • Verma, S. P., Salamone, E., & Goldin, B. (1997). Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. Biochemical and biophysical research communications, 233(3), 692-696.
  • Wichitnithad, W., Nimmannit, U., Callery, P. S., & Rojsitthisak, P. (2011). Effects of different carboxylic ester spacers on chemical stability, release characteristics, and anticancer activity of mono-PEGylated curcumin conjugates. Journal of pharmaceutical sciences, 100(12), 5206-5218.
  • Witton, C. J., Reeves, J. R., Going, J. J., Cooke, T. G., & Bartlett, J. M. (2003). Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. The Journal of Pathology: A Journal of the Pathological Society of Great Britain and Ireland, 200(3), 290-297.
  • Yallapu, M. M., Othman, S. F., Curtis, E. T., Bauer, N. A., Chauhan, N., Kumar, D.....& Chauhan, S. C. (2012). Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications. International journal of nanomedicine, 1761-1779.
  • Yu, H., Kortylewski, M., & Pardoll, D. (2007). Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nature reviews immunology, 7(1), 41-51.
  • Zhang, H. G., Kim, H., Liu, C., Yu, S., Wang, J., Grizzle, W. E.....& Barnes, S. (2007). Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1773(7), 1116-1123.
  • Zhen, L., Fan, D., Yi, X., Cao, X., Chen, D., & Wang, L. (2014). Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways. International journal of clinical and experimental pathology, 7(10), 6438.
  • Zhou, Q. M., Zhang, H., Lu, Y. Y., Wang, X. F., & Su, S. B. (2009). Curcumin reduced the side effects of mitomycin C by inhibiting GRP58-mediated DNA cross-linking in MCF-7 breast cancer xenografts. Cancer science, 100(11), 2040-2045.
  • Zhou, Y., Yau, C., Gray, J. W., Chew, K., Dairkee, S. H., Moore, D. H.....& Benz, C. C. (2007). Enhanced NFkB and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer. BMC cancer, 7, 1-15.
  • Zong, H., Wang, F., Fan, Q. X., & Wang, L. X. (2012). Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways. Molecular biology reports, 39, 48034808.
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