Diagnostic and prognostic significance of evaluation of endometrial proliferative activity in hyperplastic processes

The issues of diagnosis and treatment of proliferative processes of the uterus are the most complex and relevant in medicine. Endometrial hyperplastic processes (GPE) are among the most common gynecological diseases, occurring with a frequency of 30 to 55% [5, 22]. GPE is an extremely difficult problem of practical gynecology, which is primarily due to the fact that with a long course without treatment, it can be a background for the development of endometrial cancer [21]. According to the literature data, the frequency of "malignancy" of endometrial hyperplastic processes varies quite widely (0.25-50%) and is determined by the morphological features of the disease, the duration of its recurrence, as well as the age of patients. According to epidemiological studies, approximately 150 thousand new patients with uterine body cancer are detected annually in the world, 42 thousand of whom die.