Diagnostic value of atomic force microscopy of erythrocytes of patients with pancreatic necrosis

Introduction. The relevance of the problem of pancreatic necrosis is that currently the number of diseases, including severe forms, is steadily increasing.Purpose. To improve the results of early diagnosis of pancreatic necrosis by studying the membranes of red blood cells.Materials and methods. The erythrocyte membrane was examined using atomic electron microscopy. Additionally, neutrophilic erythrocytes were studied using this method. The study included 17 patients with pancreatic necrosis.Results. The study conducted by atomic electron microscopy in patients with pancreatic necrosis revealed changes in the membrane of erythrocytes and the shape of the nucleus and the state of the cytoplasm of neutrophilic leukocytes.Conclusions. The study of the erythrocyte membrane and the state of neutrophilic leukocytes by atomic electron microscopy in patients with pancreatic necrosis makes it possible to identify early changes in the absence of clinical manifestations and predict the possibility of purulent septic complications.