Diagnostic value of studies of mean molecular peptides in peritoneal fluid, serum and urine in patients with generalized peritonitis

On surgical treatment of 60 patients with generalized peritonitis the indicator of endogenous intoxication - mean molecular peptides (MMP) in peritoneal exudates (dialysate), serum and urine were studied in dynamics. All patients postoperatively received conventional basic intensive care. The severity of GP was determined by Manheim peritoneal index (MPI): MPI in 17 were I, in 23 - MPI II and in 20 - MPI III. Our research has shown that the depth of changes in parameters of endogenous intoxication in peritoneal exudates, serum and urine depends on the severity of patients by MPI. In all patients the level of MMP in the abdominal exudates was higher than in serum and urine. In patients with lethal results, the postoperative period is accompanied by decreasing the level of MMP in exudates and blood serum with a low content in urine. Simultaneously, the parallel study of the content of MMP in abdominal exudates, blood and urine, as well as their relationship is the most informative method of laboratory monitoring to assess the degree of endogenous intoxication and valid measure of kidney function.