Identification of structural phenotypes of osteoarthritis

Osteoarthritis (OA) is a heterogeneous disease characterized by the development of cellular stress and degradation of the extracellular matrix. In this regard, the existing practical need to identify structural OA phenotypes can be solved by developing criteria for the discrimination of structural forms of the disease.Aim: Development of identification methods and comparative characteristics of structural OA phenotypes.Methods: 62 patients with OA aged 65,9±8,8 years were examined. As a control group, 8 volunteers without clinical and x-ray signs of OA aged 60,7±7,9 years were included in the study. All patients underwent MRI of knee joints on a high-field tomograph with a magnetic field strength of 1.5 Tesla. Semi- quantitative measurements of joint tissues based on the wORMS protocol were used to evaluate MR images. Semi-quantitative scales of cartilage (CS), subchondral bone (SS), osteophytes (OS) scales were measured, and the average size of subchondral bone cysts (SCB) was measured...