Pulmonary diffusing capacity and risks of fractures in patients with COPD

The purpose of this research was to study pulmonary diffusing capacity, a condition of bone mineral density (BMD), and fracture risk assessment program FRAX in patients with COPD. 125 patients with chronic obstructive pulmonary disease (COPD) were observed. The investigated group consisted of men with long experience of smoking. The assessment of risks of osteoporotic fractures was calculated by means of computer program FRAX. A research of the external breath function was carried out by means of the multi modular installation of “Master-Lab/Jaeger” type. The pulmonary diffusing capacity (DL CO) was studied. Results of the study were obtained in the course of conducted experiment. The patients were divided into 3 groups: Dl coCO 40-60 %, DL CO > 60 %. Indicators of DL CO in patients with COPD of the 2d stage were 70,62 ± 20,28. There was a significant decrease of DL CO in the patients with COPD of the 3d stage - 53,98 ± 17,64 (p CO was detected in patients with COPD of the 4d stage 35,97 ± 15,39 (p CO. In the group of patients with Dl co 40-60 % the high risk of hip fracture was diagnosed in 29,62 % of patients. Therefore, a high risk of hip fracture was significantly more common in patients with severe pulmonary diffusion capacity reduction (p CO/VA and the risk of hip fracture was r -0,44 (p