The dynamics of cytokine pattern and extracellular hsp70 in patients with multiorgan dysfunctions after cardiac surgery

At present many researchers believe that a nucleus factor кВ and an intracellular heat shock protein 70 (HSP70) are of paramount importance for inflammatory response.The nucleus factor кВ is the potent inductor of gene expression of proinflammatory cytokines, while the intracellular HSP70 attenuates this effect. There are few available data on the relationship between the sHSP70 and the cytokine pattern in patients with multiorgan dysfunctions (MOD).The aim of the study was to determine dynamics of the cytokine pattern and sHSP70 in patients with MOD after cardiac surgery. Heterogeneous dynamics of elevated sHSP70 corresponded to the same dynamics of IL8, IL6, IL10 and depended on the course of disease. The data obtained confirm that the cytokine status in patients with multiorgan dysfunctions is uncontrolled. An elevated serum HSP70 after the first postoperative day is a marker of severe tissular injuries and septic complications and is associated with lethal outcomes.Thereare grounds to believe that an elevated serum HSP70 may potentiate the excessive cytokine reactions and contribute to the development of MODs.