Dynamics of indicators of platelets, white blood cells, and functional activity of the endothelium in young shr rats

The dynamics of composition, quantitative parameters and morphological characteristics of white blood cells and platelets, and endothelial vasodilatory function was studied in spontaneously hypertensive rats (SHR) from 5th to 12th week of life. Sequence of the changes in the study indicators was elucidated. Simultaneously with an increase in arterial blood pressure, relative lymphocyte count and platelet anisocytosis index increased in SHR compared to WKY rats at 6 weeks of age. Disturbance of endothelial vasodilatory function in SHR developed at 8 weeks of age after the development of sustained arterial hypertension and the occurrence of a number of changes in leukocyte and platelet parameters. Perhaps the change in the properties of white blood cells and platelets is one of the factors in the formation of endothelial dysfunction in hypertension.