Amiodarone-induced secondary thyroid dysfunctions in children

Introduction. The choice of effective and safe antiarrhytmic therapy for children and adolescents is relevant issue for public health. The difficulty in choising therpeutic tactics is caused by the variety of formation of arrhythmias and the side effects of drugs. Materials and Methods. The condition of thyroid system in 45 children (20 girls, 25 boys) suffering from disturbances of a rhythm within a year after the end of treatment by Ami-odaronum is analyzed. The average age of the surveyed patients was 8,26 ± 0,9 years. A comprehensive examination including an assessment of a hormonal profile (a thyroxin (T4), triodothyronine (T3), thyrotrophic hormone (TTG), antibodies to a thyroid peroxidase and a thyreoglobulin (AT to TPO and TG)), ultrasound examination (US) of a thyroid gland, a standard electrocardiography at rest (ECG) and the Holter monitoring (HM) before, in 3, 6 and 12 months of therapy was conducted. Results. It has been established that prescription of Amiodarone was followed by changes in the level the thyroid's hormones, but in most cases within normal values. Thyroido-pathya (subclinical are more often) were diagnosed for three patients. In 4.4 % of cases the hypothyroid and in 2.2 % of cases the thyrotoxicosis were detected. Discussion and Conclusions. It was shown that reception of medicine resulted in changes the sizes of a thyroid gland, but rarely followed by violations of functions.