Дискуссионные аспекты суицидологии: связь нейровоспаления с суицидальным поведением у психически здоровых людей. Сообщение I

Дискуссионные аспекты суицидологии: связь нейровоспаления с суицидальным поведением у психически здоровых людей. Сообщение I

Автор: Козлов Вадим Авенирович, Голенков Андрей Васильевич, Зотов Павел Борисович, Булыгина Ирина Евгеньевна

Журнал: Суицидология @suicidology

Статья в выпуске: 1 (54) т.15, 2024 года.

Бесплатный доступ

Накоплен большой массив литературы, в которой доказывается, что суицидальное поведение (завершённые суициды) индуцировано воспалением периферической и центральной нервной системы, реализую щимся вследствие врождённых генных полиморфизмов и/или изменения эпигеномных меток. Цель работы - систематизация сведений о роли цитокинов и воспалительных хемокинов в процессах трансляции геномных дефектов в суицидальное поведение у психически здоровых людей. В работе рассмотрена патофизиология нейровоспаления, приведены молекулярные и цитологические сведения, формирующие естественнонаучное представление о различиях нейровоспаления с участием микроглии, цито- и хемокинов и классического воспаления с активацией периферических макрофагов, Т-клеток, продуктов эйкозотетраеновой кислоты. Обсуждается роль кинуренинового пути и NMDA-рецепторов в формировании нейровоспаления и суицидального поведения. Показано как периферическое воспаление может индуцировать нейровоспаление. Патофизиология формирования суицидального поведения рассмотрена на примерах связи нейровоспаления с его проявлениями (суицидальными мыслями, суицидальными попытками и завершенными суицидами) у лиц без психических нарушений.

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Нейровоспаление, микроглия, цитокины, хемокины, суицидальное поведение (завершённый суицид), однонуклеотидные полиморфизмы, кинуренин, триптофан, nmda

Короткий адрес: https://sciup.org/140304505

IDR: 140304505   |   DOI: 10.32878/suiciderus.24-15-01(54)-3-30

Список литературы Дискуссионные аспекты суицидологии: связь нейровоспаления с суицидальным поведением у психически здоровых людей. Сообщение I

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