Дискуссионные аспекты суицидологии: связь нейро- воспаления с суицидальным поведением у лиц с психическими расстройствами. Сообщение II

Дискуссионные аспекты суицидологии: связь нейро- воспаления с суицидальным поведением у лиц с психическими расстройствами. Сообщение II

Автор: В.А. Козлов, А.В. Голенков, П.Б. Зотов

Журнал: Суицидология @suicidology

Статья в выпуске: 2 (55) т.15, 2024 года.

Бесплатный доступ

Патофизиология формирования суицидального поведения рассмотрена на примерах связи нейровоспаления с его проявлениями (суицидальными мыслями, суицидальными попытками и завершенными суицидами) у лиц с такими психическими расстройствами, как: депрессивное расстройство (большое, перипартальная депрессия), нейрогенная (нервная) анорексия, шизофрения, а также суицидами (суицидальным поведением), связанными с инфекционными заболеваниями (T. gondii, COVID-19). В результате анализа большого массива литературных данных высказывается частная гипотеза, что психически больные с суицидальным поведением (совершившие суицид), отличаются от психически больных людей, без суицидального поведения, наличием у первых генетических и/или метаболических маркеров хронического вялотекущего нейровоспаления. Признаки нейровоспаления наблюдаются также у перенесших COVID19 пациентов, по крайней мере, в раннем в постковидном периоде (до 100 дней после выздоровления) и у лиц носителей T. gondii. Эти данные сопоставлены с ранее выявленным увеличением числа суицидов в группе лиц, перенесших респираторные инфекции и лиц с аллергией на пыльцу растения. Анализ механизмов запуска нейровоспаления, ассоциируемого с суцидальными поведением (заершенными суицидами) при некоторых психических расстройствах позволяет сделать вывод об отсутствии прямой связи суицидов у психически больных с их основным заболеванием и необходимости рассматривать суцидальное поведение (завершенные суициды) у психически больных как коморбидные состояния. Суициденты без предшествующих клинических нарушений психики и с разными клинически диагностируемыми психическими расстройствами могут быть выделены в отдельную однородную группу – пациентов с суицидальным поведением. Их объединяет суицидальная активность, которая индуцируется описанными выше причинами нейровоспаления, что доказывает биологическую мультифакторную природу суицидальности.

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Нейровоспаление, суицидальное поведение (суицид), большое депрессивное расстройство, перипартальная депрессия, нейрогенная (нервная) анорексия, шизофрения, T. gondii, COVID-19

Короткий адрес: https://sciup.org/140306970

IDR: 140306970   |   DOI: 10.32878/suiciderus.24-15-02(55)-29-56

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