Disregulatory changes in surfactant and lung water balance in experimental brain ischemia and hypoxic preconditioning

The results of the study of the surfactant system, water balance of the lungs, pro- and antioxidant activity of the lung tissue in experimental one-day incomplete global cerebral ischemia caused by bilateral occlusion of the common carotid arteries are presented. The effectiveness of early and late hypoxic preconditioning performed by means of cyclic hypoxic training prior to an ischemic episode was evaluated. The experiments were performed on male rats, including sham-operated and control ones. It has been established that under conditions of ischemia, the surface activity of the surfactant decreases, which is associated with the activation of lipid peroxidation and high activity of phospholipase hydrolysis, and the blood filling of the lungs increases. The use of early and late preconditioning does not eliminate dysregulatory disorders of surfactant and lung water balance.