Effects of catechol containing fraction and other fractions of Nauclea latifolia aqueous root-bark extract on blood glucose, lipid profile and serum liver enzymes in streptozotocin - induced diabetic Wistar albino rats

Effects of catechol containing fraction and other fractions of Nauclea latifolia aqueous root-bark extract on blood glucose, lipid profile and serum liver enzymes in streptozotocin - induced diabetic Wistar albino rats

Автор: Ochalefu D.O., Adoga G.I., Luka C.D., Abu A.H.

Журнал: Журнал стресс-физиологии и биохимии @jspb

Статья в выпуске: 1 т.20, 2024 года.

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Background. Diabetes mellitus has been a menace to healthy human condition from antiquity. There has been continuous search for plant medicinal substances for drug development with an aim to managing this ailment with minimal drug side effects. In this research work, effects of fractions of aqueous root-bark extract of Nauclea latifolia on blood glucose, lipid profile and serum liver enzymes in diabetic rats were investigated. Thirty -five Wistar albino rats weighing 164.1 - 171.6 grammes were used for this study involving aqueous root-bark extract fractions A, B, C and D. The rats were divided into 7 groups of 5 rats each. Group 1 was normal non-diabetic control, group 2 was diabetic control and groups 3, 4, 5 and 6 were rats treated with 250 mg/kg body weight of varying root-bark fractions while group 7 was diabetic rats treated with 5mg/kg. body weight of glibenclamide, the standard anti-diabetic drug. Fasting blood glucose levels were determined using digital glucometer (Acuu-chek, Mannheim, Germany). Lipid profile was determined using standard procedures. Serum liver enzymes were determined using assay kits. Fraction A was analyzed using gas chromatography- mass spectroscopy and nuclear magnetic resonance spectroscopy.

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Diabetes mellitus, nauclea latifolia, aqueous extract, catechol

Короткий адрес: https://sciup.org/143182400

IDR: 143182400

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