Evaluating coagulogram abnormalities as a risk factor for recurrence of full-thickness macular hole using autologous conditioned plasma

Objective: to evaluate the activity disorder of the blood clotting factor as a potential risk factor for incomplete closure and recurrence of full-thickness macular holes (FTMHs) after surgical intervention with autologous conditioned plasma (ACP). Materials and methods. We conducted a single-center retrospective cohort study involving 62 patients (62 eyes) with primary FTMHs. The patients underwent microinvasive subtotal vitrectomy with removal of epiretinal and internal limiting membranes, application of ACP mass, and air tamponade. We divided the patients into two groups: the main group (31 patients with coagulogram abnormalities) and the control group (31 patients with normal values of coagulogram parameters). Results. Surgical outcomes demonstrated that among patients with abnormal coagulogram, recurrence of FTMH was observed in 85.7% of cases vs. 14.3% in the control group (p=0.005). When assessing the deviations in the coagulogram parameters among patients with recurrent macular hole, we revealed that in 83.3% of cases there was an increase in prothrombin time (p=0.042) and 75.0% of patients exhibited a reduction in fibrinogen concentration (p=0.049). Conclusion. Abnormalities in the coagulogram may be a risk factor for unsuccessful closure of the FTMH when using ACP mass. Relapse was detected six times more often with an increase in prothrombin time, as well as with a reduction in the blood fibrinogen content below 2.0 g/L.