Experimental study of organ dysfunction and inflammatory response in acute post-manipulation pancreatitis
Автор: Maxim A. Rantsev, Mikhail I. Prudkov, Oleg N. Chupakhin
Журнал: Saratov Medical Journal @sarmj
Статья в выпуске: 3 Vol.4, 2023 года.
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Objective: to examine the possibility of reducing the severity of organ dysfunction and inflammatory response with the L-17 compound in a model of acute post-manipulation pancreatitis (APMP). Materials and Methods. APMP was modeled on 40 rats. Laboratory rats were distributed among control (n=20, without treatment) and experimental (n=20, with the introduction of the L-17 compound) groups. The daily dose of the compound was 40 mg/kg of rat body weight. Results. APMP developed in all animals. In the control group, persistent organ dysfunction and inflammatory response corresponded to a severe course of acute pancreatitis with a mortality rate of 70%. In the experimental group, there was a decrease in the severity of organ dysfunction and inflammatory response, with a decrease in mortality down to 30%. Conclusion.Administration of the L-17 compound reduced the severity of organ dysfunction and inflammatory response in experimentally modeled APMP.
Acute post-manipulation pancreatitis, experimental pancreatitis, post-ERCP pancreatitis, substituted thiadiazines, L-17 compound
Короткий адрес: https://sciup.org/149146177
IDR: 149146177 | DOI: 10.15275/sarmj.2023.0304
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