Experimental testing of tannic acid target delivery system for correcting periodontal microcirculation

Experimental testing of tannic acid target delivery system for correcting periodontal microcirculation

Автор: Angelina A. Savkina, Ekaterina V. Lengert, Aleksey V. Ermakov, Era B. Popykhova, Tatiana V. Stepanova, Aleksey N. Ivanov

Журнал: Saratov Medical Journal @sarmj

Статья в выпуске: 1 Vol.3, 2022 года.

Бесплатный доступ

Objective: to study the effect of the targeted delivery system of tannic acid (TA) in silver alginate microcapsules on the state of gum microvasculature in rats with intact periodontium vs. experimental periodontitis. Materials and Methods. The study was conducted on 90 white rats, distributed among six groups: the control group, two groups with intact periodontium and single application of gel with microcapsules loaded/not loaded with TA, experimental periodontitis group, and two groups of animals with periodontitis and repeated application of gel with microcapsules loaded/not loaded with TA. We assessed gingival perfusion and blood flow modulation mechanisms in rats via laser Doppler flowmetry. Results. Applying gel with silver microcapsules to an intact gum in rats caused 7.5% transient increase in perfusion and activation of microcirculation modulation. Loading microcapsules with TA reduced the severity of transient microcirculatory changes. Using gel with TA-loaded capsules in rats with periodontitis allowed achieving a more pronounced normalization of perfusion and mechanisms of microcirculation modulation vs. using gel containing microcapsules without active components. Conclusion. Loading alginate microcapsules with silver ions and TA yielded reduction of the irritating effect on gingival mucosa accompanied by an increase in the effectiveness of correcting microcirculatory disorders in periodontitis.

Еще

Periodontitis, microcirculation, tannic acid

Короткий адрес: https://sciup.org/149139020

IDR: 149139020   |   DOI: 10.15275/sarmj.2022.0103

Список литературы Experimental testing of tannic acid target delivery system for correcting periodontal microcirculation

  • Kornman KS. Future of preventing and managing common chronic inflammatory diseases. J Periodontol 2020; 91 (1): 12-8. https://doi.org/10.1002/JPER.20-0134
  • Morand D, Davideau J-L, Clauss F, et al. Cytokines during periodontal wound healing: Potential application for new therapeutic approach. Oral Dis 2017; (23): 300-11. https://doi.org/10.1111/odi.12469
  • Isola G, Polizzi A, Iorio-Siciliano V, et al. Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: A randomized, controlled clinical trial. Clin Oral Investig 2021; 25 (3): 1035-45. https://doi.org/10.1007/s00784-020-03397-z
  • Şuhani MF, Băciuţ G, Băciuţ M, et al. Current perspectives regarding the application and incorporation of silver nanoparticles into dental biomaterials. Clujul Med 2018; 91 (3): 274-9. https://doi.org/10.15386/cjmed-935
  • Craciunescu O, Seciu A-M, Manoiu VS, et al. Biosynthesis of silver nanoparticles in collagen gel improves their medical use in periodontitis treatment. Particulate Science and Technology 2019; 37 (6): 757-63.
  • https://doi.org/10.1080/02726351.2018.1455780
  • Siczek K, Zatorski H, Chmielowiec-Korzeniowska A, et al. Evaluation of anti-inflammatory effect of silver-coated glass beads in mice with experimentally induced colitis as a new type of treatment in inflammatory bowel disease. Pharmacol Rep 2017; 69 (3): 386-92.
  • https://doi.org/10.1016/j.pharep.2017.01.003
  • Naik K, Kowshik M. The silver lining: Towards the responsible and limited usage of silver. J Appl Microbiol 2017; (123): 1068-87. https://doi.org/10.1111/jam.13525
  • Tóthová L, Celec P. Oxidative stress and antioxidants in the diagnosis and therapy of periodontitis. Front Physiol 2017; (8): 1055. https://doi.org/10.3389/fphys.2017.01055
  • Bunte К, Hensel А, Beikler Т. Polyphenols in the prevention and treatment of periodontal disease: A systematic review of in vivo, ex vivo and in vitro studies. Fitoterapia 2019; (132): 30-9. https://doi.org/10.1016/j.fitote.2018.11.012
  • Radafshar G, Ghotbizadeh M, Saadat F, et al. Effects of green tea (Camellia sinensis) mouthwash containing 1% tannin on dental plaque and chronic gingivitis: A double-blinded, randomized, controlled trial. J Invest Clin Dent 2017; (8): e12184. https://doi.org/10.1111/jicd.12184
  • Hu F, Zhou Z, Xu Q, et al. A novel pH-responsive quaternary ammonium chitosan-liposome nanoparticles for periodontal treatment. Int J Biol Macromol 2019; 15 (129): 1113-9. https://doi.org/10.1016/j.ijbiomac.2018.09.057
  • Gjoseva S, Geskovski N, Sazdovska SD, et al. Design and biological response of doxycycline loaded chitosan microparticles for periodontal disease treatment. Carbohydr Polym 2018; 15 (186): 260-72. https://doi.org/10.1016/j.carbpol.2018.01.043
  • Joshi D, Garg T, Goyal AK, et al. Advanced drug delivery approaches against periodontitis. Drug Deliv 2016; 23 (2): 363-77. https://doi.org/10.3109/10717544.2014.935531
  • Ionel A, Lucaciu O, Moga M, et al. Periodontal disease induced in Wistar rats – Experimental study. HVM Bioflux 2015; 7 (2): 90-5.
  • Lengert EV, Savkina AA, Ermakov AV, et al. Influence of the new formulation based on silver alginate microcapsules loaded with tannic acid on the microcirculation of the experimental periodontitis in rats. Mater Sci Eng C Mater Biol Appl 2021; (126): 112144. https://doi.org/10.1016/j.msec.2021.112144.
  • Yin IX, Zhang J, Zhao IS, et al. The antibacterial mechanism of silver nanoparticles and its application in dentistry. Int J Nanomedicine 2020; 17 (15): 2555-62. https://doi.org/10.2147/IJN.S246764
  • Hadrup N, Sharma AK, Loeschner K. Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review. Regul Toxicol Pharmacol 2018; (98): 257-67. https://doi.org/10.1016/j.yrtph.2018.08.007
  • Ho KY, Tsai CC, Huang JS, et al. Antimicrobial activity of tannin components from Vaccinium vitis-idaea L. Journal of Pharmacy and Pharmacology 2001; (53): 187-91. https://doi.org/10.1211/0022357011775389
  • Curuțiu C, Dițu LM, Grumezescu AM, et al. Polyphenols of honeybee origin with applications in dental medicine. Antibiotics 2020; 9 (12): 856. https://doi.org/10.3390/antibiotics9120856
  • Casolaro M, Casolaro I, Akimoto J, et al. Antibacterial properties of silver nanoparticles embedded on polyelectrolyte hydrogels based on α-amino acid residues. Gels 2018; 4(2): 42. https://doi.org/10.3390/gels4020042
Еще
Статья научная
SciUp 2024 © 2024 ©