Фармакологические аспекты лечения острой гликозидной интоксикации

Фармакологические аспекты лечения острой гликозидной интоксикации

Автор: Шперлинг М.И., Кручинин Е.Г., Гоголевский А.С.

Журнал: Вестник медицинского института "РЕАВИЗ": реабилитация, врач и здоровье @vestnik-reaviz

Рубрика: Клиническая медицина

Статья в выпуске: 4 (52), 2021 года.

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Несмотря на активное внедрение хирургических методов лечения сердечной патологии и новых синтетических кардиотонических средств, сердечные гликозиды (СГ) остаются важной составляющей фармакологической терапии заболеваний сердца. Более того, интерес к данной группе препаратов только возрастает с учетом открытия новых фармакологических эффектов, таких как противоопухолевый и противовирусный. Однако, несмотря на многолетний опыт применения, вопрос ведения пациентов с симптомами как острой, так и хронической интоксикации СГ остается одним из ведущих. В обзоре литературы приводится краткий исторический очерк отравлений сердечными гликозидами, описываются особенности фармакокинетики и фармакодинамики данной группы препаратов. Рассмотрена клиническая картина отравлений СГ. Проанализированы современные представления и ограничения антидотной терапии, а также особенности патогенетического и симптоматического лечения пациентов с острой гликозидной интоксикацией.

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Сердечные гликозиды, гликозидная интоксикация, fab-фрагменты антител к дигоксину

Короткий адрес: https://sciup.org/143177458

IDR: 143177458   |   DOI: 10.20340/vmi-rvz.2021.4.CLIN.1

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