Features of erythrocyte electrophoretic mobility in programmed hemodialysis patients
Автор: Ekaterina S. Boldyreva, Egor V. Kudryavtsev
Журнал: Saratov Medical Journal @sarmj
Статья в выпуске: 1 Vol.3, 2022 года.
Бесплатный доступ
Objective: to analyze the electrophoretic properties of erythrocytes in patients receiving programmed hemodialysis treatment. Materials and Methods. The study included 100 patients with an established diagnosis of stage 5D chronic kidney disease, receiving programmed hemodialysis treatment. The control group included 17 healthy blood donors. The following indicators of erythrocyte electrophoretic activity were evaluated: oscillation amplitude, percentage of motile cells, ellipticity, and aggregation index. Results. Compared with the control group, we revealed significant changes in the amplitude of oscillations and the percentage of motile cells (p-0.001). No significant gender-dependent differences were observed (p-0.05). Statistically significant differences between young and senile age groups (p=0.048) were observed in the average oscillation amplitude, whereas ellipticity differed significantly in middle-aged vs. senile patients (p=0.040) and elderly vs. senile subjects (p=0.035). As for the effect of hemodialysis treatment duration, a reduction in the oscillation amplitude was observed when comparing maximum with minimum duration: less than 1 year (p=0.029) and 1 year (p=0.035). Aggregation index values were the highest in the groups with the minimum (p=0.044) and maximum (p=0.035) dialysis duration. Conclusion. In hemodialysis patients, the oscillation amplitude of erythrocytes was significantly reduced, with assumed tendency for further decrease associated with duration of hemodialysis treatment.
Electrophoretic mobility of red blood cells, chronic kidney disease, hemodialysis
Короткий адрес: https://sciup.org/149139017
IDR: 149139017 | DOI: 10.15275/sarmj.2022.0101
Список литературы Features of erythrocyte electrophoretic mobility in programmed hemodialysis patients
- Herzog CA, Asinger RW, Berger AK, et al. Cardiovascular disease in chronic kidney disease. A clinical update from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney International 2011; 80 (6): 572-86. https://doi.org/10.1038/ki.2011.223
- Levin A, Stevens P, Bilous R, et al. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International Supplements 2013; 3 (1): 1-136. https://www.kidney-international.org/
- Carracedo J, Alique M, Vida C, et al. Mechanisms of cardiovascular disorders in patients with chronic kidney disease: A process related to accelerated senescence. Frontiers in Cell and Developmental Biology 2020; (8): 185. https://doi.org/10.3389/fcell.2020.00185
- Martusevich AK, Martusevich AA, Deryugina AV, et al. Electrophoretic study of erythrocyte membranes under the action of reactive oxygen species and nitric oxide. Biomedicine 2019; 15 (1): 102-12. [In Russ.] https://doi.org/10.33647/2074-5982-15-1-102-112.
- Deryugina AV, Martusevich AA, Khlamova YuN, et al. Electrophoretic mobility of erythrocytes in inflammation. Vyatka Medical Bulletin 2016; 4 (52): 57-60. [In Russ.]
- Deryugina AV, Ivashchenko MN, Ignatiev PS, et al. Alterations in the phase portrait and electrophoretic mobility of erythrocytes in various diseases. Contemporary Technology in Medicine 2019; 11 (2): 63-8. [In Russ.] https://doi.org/10.17691/stm2019.11.2.09
- Deryugina AV, Martusevich AA, Antipenko AA, et al. Effect of chronic stress on electrokinetic properties and oxidative metabolism in erythrocytes. Bioradicals and Antioxidants 2015; 2 (2): 26-35. [In Russ.]
- Obukhova LM, Erlykina EL, Kopytova TV, et al. The role of lipids in forming the electrokinetic properties of red blood cells in solid tumors and psoriasis. Kazan Medical Journal 2015; 96 (5): 764-8. [In Russ.] https://doi.org/10.17750/KMJ2015-764
- Kazakova IA, Ievlev YN. Electrophoretic mobility of erythrocytes in patients with stage 5 chronic kidney disease on hemodialysis with different levels of arterial pressure. Therapy 2019; 5 (2): 30-5. [In Russ.]
- Krylov VN, Deryugina AV, Antipenko EA. The electrophoretic mobility of erythrocytes as an approach to assess the function of the adrenal cortex in stress and pathological body conditions. Yu.A. Ovchinnikov Bulletin of Biotechnology and Physical and Chemical biology 2013; 9 (2): 39-42. [In Russ.]
- Olszewska M, Bober J, Wiatrow J, et al. The impact of hemodialysis on erythrocyte membrane cytoskeleton proteins. Advances in Hygiene & Experimental Medicine 2015; (69): 165-75.
- Tukin VN, Fedorova MZ. Age-dependent changes in blood biochemical indices and their relationship with the stiffness of membranes in hemocytes of healthy men and women. Belgorod State University Scientific Bulletin 2012; 18 (3): 155-60. [In Russ.]
- Kazantsev AV, Suetenkov DE, Andronov EV, et al. Gender-related features of blood rheological properties (plasma viscosity, aggregation and deformation properties of erythrocytes) in patients with chronic generalized periodontitis. Saratov Journal of Medical Scientific Research 2014; 10 (1): 56-61. [In Russ.]
- Baskurt O, Meiselman H. Erythrocyte aggregation: Basic aspects and clinical importance. Clinical Hemorheology and Microcirculation 2013; 53 (1-2): 23-37. https://doi.org/10.3233/CH-2012-1573
- Podzolkov VI, Koroleva TV, Pisarev MV, et al. Disorders of microcirculation and red blood cell functional condition as a cardiovascular risk factor in metabolic syndrome. Rational Pharmacotherapy in Cardiology 2018; 14 (4): 591-7. [In Russ.] https://doi.org/10.20996/1819-6446-2018-14-4-591-597
