Features of intercellular interaction of platelets and neutrophils expressing adhesion molecules in psoriasis
Автор: Nikolay V. Sherstennikov, Sergey L. Kashutin, Alexandra K. Sherstennikova, Oleg V. Kalmin, Valentin I. Nikolaev
Журнал: Saratov Medical Journal @sarmj
Статья в выпуске: 3 Vol.2, 2021 года.
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Objective: to determine the features of intercellular interaction of platelets with neutrophils expressing adhesion molecules in psoriasis patients. Material and Methods. The study included 82 patients 20-60 years of age with a plaque psoriasis or pustular psoriasis. As a control group, 50 virtually healthy individuals 20-60 years old were examined. The study of the adhesion molecules spectrum on neutrophils was carried out on a Beckman Coulter FC-500 flow cytometer (USA) using monoclonal antibodies. The platelet-neutrophil aggregates were determined sensu the method by Yu.A. Vitkovsky et al. (2006). Results. In patients with psoriasis, compared with the control group, few intercellular contacts of neutrophils with platelets were revealed. Low values of platelet-neutrophil aggregates with 3, 4, and 5 lobes in the nucleus were observed. The formation of aggregates statistically significantly correlated with the expression of LFA-1 and PECAM-1 adhesion molecules by mature neutrophils. Conclusion. Low rates of intercellular interaction of platelets with three-, four-, and five-lobed neutrophils in psoriasis were indicative of their augmented migration from the peripheral blood to the epidermis. The adhesion molecules LFA-1 and PECAM-1 play a key role in the migration of platelet-neutrophil aggregates.
Adhesion molecules, neutrophils, platelets, psoriasis
Короткий адрес: https://sciup.org/149139008
IDR: 149139008 | DOI: 10.15275/sarmj.2021.0303
Список литературы Features of intercellular interaction of platelets and neutrophils expressing adhesion molecules in psoriasis
- Mordovtsev VN, Mushet GV, Albanova VI. Psoriasis. Kishinev, 1991; 185 p. [In Russ.]
- Tsvetkova GM, Mordovtseva VV, Vavilov VN, Mordovtsev AM. Pathological Morphology of Skin Diseases: A Physician’s Guide. Мoscow: Meditsina, 2003; 456 p. [In Russ.]
- Karaulov AV, Khedri F, Kurnikov GYu, et al. Serum levels of soluble adhesion molecules and histocompatibility molecules in psoriasis. Immunology 2016: 37 (2): 84-9. [In Russ.]
- Smith CH, et al. Cell trafficking and role of adhesion molecules in psoriasis. Clinics in Dermatology 1995; 13 (2): 151-60. https://doi.org/10.1016/0738-081x(95)93821-5
- Cabrijan L, Lipozenсiс J. Adhesion molecules in keratinocytes. Clinics in Dermatology 2011; 29 (4): 427-31. https://doi.org/10.1016/j.clindermatol.2011.01.012
- Bressan A, Pereira D, Medeiros PM, et al. Evaluation of ICAM-1 expression and vascular changes in the skin of patients with plaque, pustular, and erythrodermic psoriasis. Int J Dermatol 2018; 57 (2): 209-16. https://doi.org/10.1111/ijd.13883
- Serebryanaya NB, Shanin SN, Fomicheva EE, et al. Platelets as activators and regulators of inflammatory and immune responses. Part 1. The main characteristics of platelets as inflammatory cells. Medical Immunology 2018; 20 (6): 785-96. [In Russ.] https://doi.org/10.15789/1563-0625-2018-6-785-796
- Barinov EF, Grigoryan HV, Balykina AO, et al. Platelet-leukocyte aggregates of circulating blood as an early indicator of chronic obstructive pyelonephritis relapse. Clinical Nephrology 2017; (4): 37-41. [In Russ.]
- Vitkovsky YuA, Kuznik BI, Solpov AV. Pathogenetic significance of lymphocyte-platelet adhesion. Medical Immunology 2006; 8 (2): 745-8. [In Russ.] https://doi.org/10.15789/1563-0625-2006-5-6-745-753
- Nikolashina OE, Bakulev AL. On the relationship between congenital and adaptive immunity in psoriasis. Saratov Journal of Medical Scientific Research 2015; 11 (3): 421-3. [In Russ.]
- Matosova EV, Andryukov BG. Morphofunctional characteristics of neutrophil defense mechanisms in bacterial infections and their contribution to the pathogenesis of proinflammatory responses. Hematology and Transfusiology 2017; 62 (4): 223-9. [In Russ.]
