Phenotypic features of cells in urinary sediment of patients with non-invasive bladder cancer

More than 430,000 new cases of bladder cancer are diagnosed every year in the world, and approximately 70- 80 % of patients present with non-invasive disease. To improve the effectiveness of early detection of bladder cancer, high sensitivity diagnostic tools should be used. In our study we used flow cytometry to determine surface markers in urinary sediment cells of patients with bladder cancer. The analysis of the phenotypic features of urinary sediment cells showed an increase in the relative content of CD13+ cells in patients with non-invasive bladder cancer in comparison with the control group. In addition, there was a 4.8-fold increase in cells expressing CD15 surface antigen (p