Phenotypic peculiarities of pigs during embryogenesis under the influence of integration of human growth hormone releasing factor gene

The authors investigated the influence of integration of human growth hormone releasing factor gene on intensity of growth and development of transgenic pigs at the embryonic period of development. The weight and linear characteristics of growth in transgenic embryos and also the structure-functional peculiarities of glandular organs (liver, pancreas and thyroid gland, fundus of stomach and duodenum) were determined. It was established that the integration of foreign gene do not causes significant changes of inorphometric parameters of glandular organs at the period of em-bryogenesis; however it results in the changes in ratio of cell's nucleic acids. The transgenic embryos in contrast to control embryos have the decrease in DNA content and at the same time the increase in RNA content in the cells average to 3,5-10 %.