The physico-chemical features of imidazolides, their mutagenic activity and Drosophila melanogaster ability to adapt to them

It was shown that imidazole and its methyl and sulphuril derivates differ on their ability to induce dominant lethal mutations in Drosophila melanogaster imago both in toxic and sub-lethal doses. The mutagenic activity correlated with molecular mass, volume and sum dipole moment of tested substances. The short action of non-toxic imidazolides on Drosophila melanogaster imago did not developed the adaptations decreasing the mutagenic effects of substances. The long-term action of non-toxic doses in larval period of Drosophila melanogaster led to development of adaptive answer expressed in valuable decrease of dominant lethal mutations induced by sub-lethal doses of these substances in comparing with the number of mutations induced by right substances action. The preliminary short or long-term action of non-toxic inimazole doses did not develop the adaptive answer in Drosophila melanogaster in the case of sub-lethal dose. The role of physico-chemical parameters of imidasolides in adaptive answer development.