Formation of endothelial dysfunction in complicated postoperative period in urolithiase

Introduction. Urea disease is one of the most common diseases in the world, affecting almost 3% of the population, mainly people of working age from 40 to 50 years, which determines the relevance of a comprehensive study of this disease. The aim of the study was to study the mechanism of endothelial dysfunction formation in the complicated course of the postoperative period in patients with urolithiasis. Materials and methods. The study included 90 patients with urolithiasis who had operational interventions in the urology department of the Russian Railways-Medicine Clinical Hospital of Krasnoyarsk between 2017 and 2019. The age of patients with urolithiasis in our study was from 19 to 82 years, with a median age of 54 [37; 69] years. Results. The risk of postoperative complications in urolithiasis increases with increasing indices of terminal and total blebbing of plasma membrane of lymphocytes and increasing expression of lymphocytes activated by CD 31 and CD 38. Conclusion. Patients with a predicted risk of developing complications in the postoperative period need a choice of treatment tactics and postoperative therapy aimed at preventing the development of a complicated course of the disease.