Signs of thrombotic state of readiness with increase of physical activity

Aim. The paper aims to assess the effect of a single intensive physical exercise of varying duration on the hemostasis system, microvasculature, and endothelium of rats. Materials and methods. The hemostasis system and microvasculature were investigated in 60 mature male Wistar white rats after a 4-hour and 8-hour physical exercise on a rat treadmill. Results. It was found that a 4-hour exercise resulted in an increase in the aggregation function of platelets with a subsequent increase in their number and hypercoagulation against the decrease in plasma anticoagulant activity. An 8-hour exercise increased the negative changes identified before. Thus, there was an increase in soluble fibrin monomer complexes, a decrease in fibrinogen and platelets in the blood, a decrease in plasma anticoagulant and fibrinolytic activity, the development of endothelial dysfunction and congestive phenomena in the microcirculation area. Conclusion. The increase in the duration of stress exposure training from 4 to 8 hours leads to an increase in the severity of signs of the thrombotic state of readiness.