Frequency of cardiovascular risk factors among the population of Ferghana valley

Actuality of the theme. Atherosclerosis with its basic clinical manifestations keeps leading in structure of illness and death. At the same time in last years achieved high advances in decreasing of cardiovascular death in many developed countries. In experts’ judgment, this effects show introduction of atherosclerosis primary prophylaxis rules, healthy life-style, basic principles of conclusive medicine and so results of polycentric clinical researches [1].

Disease of cardiovascular system is one of actual problems of healthcare of Republic of Uzbekistan. Analysis of mortality reasons showed, that death-rate from CVD staying as prevalent in structure of total mortality, it made 56% (79120 per.) in 2005, and 59,3% (79239 per.) in 2009 years [2]. Comparative analysis of mortality rate from CVD among people able-bodied age (to 100 thousand able-bodied populations in age of 2564 years, in a year) show, that Uzbekistan among countries of CIS takes 8th place (among women 121,3 and among men 220,7 to 100 thousand able-bodied populations). Although, mortality substantially lesser than Russian Federation (among women 241,9 and among men 762,8), Kazakhstan (252,2 and 672,3), Ukraine and Belorussian, but more than European countries, such as Germany, France, Sweden and others (37 and 107,4 etc.) [3].

Important aspect of CVD prophylaxis is detection of persons with disturbance of lipids’ metabolism and without clinical symptoms of IHD. Estimation of individual fatal risk, so possibility of death from IHD, peripheral atherosclerosis and stroke on persons without clinical symptoms of enumerated diseases in 10 years takes on table of Systemic Coronary Risk Evaluation (SCORE). Is shown that, decrease of a level such powerful risk factors (RF) such as, hypercholesterolemia (HChE) and arterial hypertonia (AH) - leads to significant (to 20-40%) reduction of total death from CVD [4].

Aim of the research was to study the frequency of CVD RF, such as smoking, AH, HChE men and women in different age.

Materials and methods of the research. The object of study is based on 382 patients, in the age of 25-69 years, which haven’t clinical signs of atherosclerosis. Performed one-timely patient examination, with method of random sample and filling specially prepared questionnaire.

Results and discussion. Examined 382 patients: 33.2% (127 per.) of them men and 66.8% (255 per.) women (p˂0,0001). Results of the study showed, that among examined patients smoking was revealed in 70.8% men (90 per.) and 5.1% (13 per.) women. Overweight/obesity and AH revealed approximately in equal parts, in 55.1% (70 per.) and 51.9% (66 per.) men, and in 54.1% (138 per.) and 56.1% (143 per.) women, accordingly

Figure 1. Frequency of risk factors in men and women.

Note: ***** - P < 0,0001.

Overweight/obesity and AH revealed approximately in equal parts, in 55.1% (70 per.) and 51.9% (66 per.) men, and in 54.1% (138 per.) and 56.1% (143 per.) women, accordingly.

■ 0   ■ 1-2   13-4  ■■>5

Figure 2. Association of risk factors according to gender.

Analyze of RF (age, gender, smoking, abdominal obesity, AH, DM, HChE and family history of premature CVD) showed, that 10.6% (27 per.) of women were had no one RF. 1-2 RF were had in 15.7% (20 per.) men and reliably often in women 47.5% (121 per.) and was reliable (p˂0,001) (Figure 2).

Combination of 3-4 RF had 57.5% (73 per.) men and 40% (102 per.) women (p˂0,001), 5 and more RF revealed on 26.8% (34 per.) and 1.9% (5 per.) men and women (p˂0,005), accordingly.

Conclusion.

• 1.    Every second men and women had AH, overweight/obesity. Smoking became as the

  main RF in men and was revealed in 70.9% (p˂0,0001).

• 2.    Among residents of Fergana valley 84.3% men and 41.9% women had 3 and more

  RF (p˂0,0001), amount of which increased according to age.