Functional status of microphagocytes of the peripheral blood and a range of cytokines produced by them in cervical cancer

Phagocytic and cytotoxic activity as well as a range of produced cytokines was investigated in a peripheral blood neutrophils (NF) by 109 primary cervical cancer patients at stage of I–IV by FIGOs to be assess the possibility of pro-tumoral activities. An increase in the absolute and relative number of NF, a decrease of phagocytic activity, a decrease of bactericidal which expressed at stage Ib–IIa was shown in the dynamics of tumor progression. The range of cytokines produced by neutrophils was characterized by a marked increase in the level of IL-10 and a reduce of IL-1β, IFN-γ, IL-6, TNF-α on the Ib–IIa stage of disease.